1例SAPHO综合征服用硫酸羟氯喹引起急性泛发性发疹性脓疱病用药分析  

Medication Analysis of Acute Generalized Exanthematous Pustulosis Caused by Hydroxychlo⁃roquine Sulfate in SAPHO Syndrome:A Case Report

作　　者：陈玉[1] CHEN Yu(West China Nursing College,West China Hospital,Sichuan University,Chengdu,Sichuan,China 610000)

机构地区：[1]四川大学华西医院华西护理学院,四川成都610000

出　　处：《中国药业》2024年第S02期78-80,共3页China Pharmaceuticals

摘　　要：目的探讨SAPHO综合征患者使用硫酸羟氯喹后引起急性泛发性发疹性脓疱病(AGEP)的治疗方法。方法回顾性分析1例SAPHO综合征患者AGEP的发病过程,在口服枸橼酸托法替布、骨松宝颗粒的基础上加予硫酸羟氯喹后,患者由水肿进展为AGEP。评估患者皮损情况及近期所用药物。结果考虑为硫酸羟氯喹致敏可能性大,医师将其停用并予甲泼尼龙琥珀酸钠、氯化钾缓释片、倍他米松尿素霜等药物,经过14天的积极治疗和精心护理,患者病情好转出院。结论该病例为硫酸羟氯喹引发的AGEP,提示临床医师在应用硫酸羟氯喹时应考虑其可能引起的皮肤损伤。Objective To investigate the treatment method of acute generalized exanthematous pustulosis(AGEP)caused by hydroxychloroquine sulfate in patients with SAPHO syndrome.Methods The pathogenesis of AGEP in a patient with SAPHO syndrome was analyzed retrospectively.After adding hydroxychloroquine sulfate to oral administration of tofacitinib citrate and Gusongbao Granules,the patient experienced from edema to AGEP.The patient′s skin lesions and recent medications were evaluated.Results Considering the possibility of sensitization by hydroxychloroquine sulfate,the physicians stopped its use and gave methylprednisolone sodium succinate,Potassium Chloride Sustained-Release Tablets,and Betamethasone Urea Cream,etc.The patient was discharged from the hospital in a better condition after 14 d of active treatment and careful care.Conclusion AGEP in the patient is caused by hydroxychloroquine sulfate,which suggests that clinicians should consider the possible skin damage caused by hydroxychloroquine sulfate when applying it.

关 键 词：SAPHO综合征 硫酸羟氯喹 急性泛发性发疹性脓疱病 药学监护 

分 类 号：R681[医药卫生—骨科学]