How to properly evaluate cardiac vagal tone in oncology studies:a state-of-the-art review  

作　　者：Pierrick Martinez Marilyne Grinand Saïda Cheggour Jérôme Taieb Géraud Gourjon 

机构地区：[1]Scientific and Osteopathic Research Department,Institut de Formation en Ostéopathie du Grand Avignon,403 Rue Marcel Demonque,Avignon,France [2]Département de recherche clinique,Centre hospitalier d’Avignon,305A Rue Raoul Follereau,Avignon,France [3]Service de cardiologie,Centre hospitalier d’Avignon,305A Rue Raoul Follereau,Avignon,France [4]Service de cardiologie,Centre Hospitalier du pays d’Aix-Pertuis,Avenue des Tamaris Aix-en-Provence,France

出　　处：《Journal of the National Cancer Center》2024年第1期36-46,共11页癌症科学进展（英文）

摘　　要：Heart rate variability(HRV)analysis provides an assessment of cardiac vagal tone and consequently global cardiac health as well as systemic condition.In systemic diseases such as cancer and during treatments that affect the whole body,like chemotherapy,the vagus nerve activity is low and deregulated.Some studies focus on using HRV to predict mortality in oncology.However,in cancer patients,systemic alterations substantially increase artifacts during HRV measurement,especially atrial ectopic beats.Moreover,HRV may be altered by various factors(duration and time of measurement,breathing,drugs,and other confounding factors)that alter each metric in different ways.The Standard Deviation of all Normal to Normal intervals(SDNN)is the most commonly used metric to evaluate HRV in oncology,but it does not appear to be specific to the cardiac vagal tone.Thus,cardiac vagal activity diagnosis and vital prognosis of cancer patients can be biased.Our review presents the main HRV metrics that can be currently used in oncology studies and their links with vagus nerve and cancer.We present the influence of external factors and the required duration and time of measurement.Considering all these parameters,this review proposes seven key points for an assessment of HRV and cardiac vagal tone in patients with cancer.

关 键 词：Clinical oncology Heart rate control Vagal nerve stimulation Autonomic nervous system Evaluation methodology 

分 类 号：R54[医药卫生—心血管疾病]