氟康唑注射液联合硝酸咪康唑乳膏治疗化脓性中耳炎合并真菌感染的临床效果  

Clinical Efficacy of Fluconazole Injection Combined with Miconazole Nitrate Cream in the Treatment of Suppurative Otitis Media with Fungal Infection

作　　者：王红梅 黄萌萌 王玉芝[1] WANG Hongmei;HUANG Mengmeng;WANG Yuzhi(Department of Otolaryngology,the Second People's Hospital of Liaocheng,Linqing 252600,China;不详)

机构地区：[1]聊城市第二人民医院耳鼻咽喉科,山东临清252600

出　　处：《中国医学创新》2024年第32期117-121,共5页Medical Innovation of China

摘　　要：目的:探讨氟康唑注射液联合硝酸咪康唑乳膏治疗化脓性中耳炎(SOM)合并真菌感染(FI)的临床效果。方法:选取2021年8月—2023年7月聊城市第二人民医院收治的共计78例SOM合并FI患者,以随机数字表法将其分成研究组(39例)与对照组(39例),两组均采用左氧氟沙星滴耳液冲洗外耳道,对照组在此基础上给予硝酸咪康唑乳膏治疗,研究组给予氟康唑注射液联合硝酸咪康唑乳膏治疗,比较两组临床疗效、症状消失时间、听力功能、炎症因子、复发率、不良反应。结果:对照组治疗总有效率为74.36%(29/39),研究组为92.31%(36/39),研究组较对照组高,差异有统计学意义(P<0.05);研究组症状(耳痛、鼓膜充血、流脓、发热)消失时间均较对照组早,差异均有统计学意义(P<0.05);两组治疗后气导阈值、骨导阈值均较治疗前下降,研究组均较对照组低,差异均有统计学意义(P<0.05);两组治疗后白细胞介素-1β(IL-1β)、白细胞介素-8(IL-8)水平均较治疗前下降,研究组均较对照组低,差异均有统计学意义(P<0.05);研究组复发率为2.78%(1/36),较对照组的27.59%(8/29)低,差异有统计学意义(P<0.05);对照组不良反应发生率为10.26%(4/39),研究组为5.13%(2/39),两组比较差异无统计学意义(P>0.05)。结论:SOM合并FI患者给予氟康唑注射液联合硝酸咪康唑乳膏治疗,能够提升临床疗效,促进症状消失时间缩短,改善听力功能、炎症反应,降低复发风险,安全性较高。Objective:To explore the clinical efficacy of Fluconazole Injection combined with Miconazole Nitrate Cream on suppurative otitis media(SOM)with fungal infection(FI).Method:A total of 78 patients with SOM with FI from August 2021 to July 2023 who were admitted in the Second People's Hospital of Liaocheng were selected and divided into the study group(39 cases)and the control group(39 cases)by random number table method.Both groups were washed with Levofloxacin Ear Drops to the external ear canal.The control group was treated with Miconazole Nitrate Cream on this basis,while the study group was treated with Fluconazole Injection combined with Miconazole Nitrate Cream.The clinical efficacy,time of symptom disappearance,hearing function,inflammatory factors,recurrence rate and adverse reactions were compared between the two groups.Result:The total effective rate was 74.36%(29/39)in the control group and 92.31%(36/39)in the study group,which was higher than that in the control group,the difference was statistically significant(P<0.05).The disappearance time of symptoms(earache,tympanic membrane congestion,pus,fever)in the study group was earlier than those in the control group,the differences were statistically significant(P<0.05).After treatment,the air conduction threshold and bone conduction threshold in both groups were lower than those before treatment,and those of the study group were lower than those of the control group,the differences were statistically significant(P<0.05).After treatment,interleukin-1β(IL-1β)and interleukin-8(IL-8)levels in both groups were lower than those before treatment,and those of the study group were lower than those of the control group,the differences were statistically significant(P<0.05).The recurrence rate of the study group was 2.78%(1/36),which was lower than 27.59%(8/29)of the control group,the difference was statistically significant(P<0.05).The incidence of adverse reactions was 10.26%(4/39)in the control group and 5.13%(2/39)in the study group,there was no significant dif

关 键 词：化脓性中耳炎 真菌感染 氟康唑注射液 硝酸咪康唑乳膏 

分 类 号：R764.21[医药卫生—耳鼻咽喉科]