育龄期妇女多囊卵巢综合征炎症标志物与代谢紊乱的关系  

Association between Inflammatory Markers and Metabolic Disorders in Women of Reproductive Age with Polycystic Ovary Syndrome

作　　者：陈蕾 李佳宁 CHEN Lei;LI Jianing(Laboratory Department,Jilin Chemical Industry Hospital,Jilin 132000,China;不详)

机构地区：[1]吉林市化工医院检验科,吉林吉林132000

出　　处：《中国医学创新》2024年第34期97-101,共5页Medical Innovation of China

摘　　要：目的:探讨育龄期妇女多囊卵巢综合征(PCOS)炎症标志物与代谢紊乱的相关性。方法:回顾性分析2019年1月—2023年5月在吉林市化工医院就诊的300例PCOS育龄期患者和300例女性健康体检者的临床资料,PCOS育龄期女性患者纳入PCOS病例组,女性健康体检者纳入对照组。比较两组血清代谢和炎症标志物的差异。同时采用Pearson相关系数分析PCOS病例组代谢和炎症标志物的相关性。结果:PCOS病例组费里曼-高威(F-G)评分、促黄体生成素(LH)、卵泡刺激素(FSH)、总睾酮(TT)、胰岛素抵抗指数(HOMA-IR)、空腹血浆胰岛素(FINS)、C反应蛋白(CRP)、降钙素原(PCT)、肿瘤坏死因子-α(TNF-α)及白细胞介素-6(IL-6)水平均高于对照组,差异均有统计学意义(P<0.05)。PCOS患者血清CRP水平与LH、FSH、HOMA-IR均呈正相关(r=0.897、0.148、0.767,P<0.05),血清TNF-α与F-G评分、FINS、LH、FSH、HOMA-IR均呈正相关(r=0.994、0.402、0.453、0.136、0.399,P<0.05),血清IL-6水平与F-G评分、FINS、LH、FSH、TT、HOMA-IR均呈正相关(r=0.253、0.612、0.199、0.202、0.829、0.948,P<0.05)。结论:PCOS育龄期女性患者存在慢性炎症和代谢紊乱,且炎症标志物水平和代谢紊乱相关。Objective:To explore the correlation between inflammatory markers and metabolic disorders in women of reproductive age with polycystic ovary syndrome.Method:Clinical data of 300 PCOS patients of childbearing age and 300 female health examination subjects treated in Jilin Chemical Industry Hospital from January 2019 to May 2023 were retrospectively analyzed.PCOS female patients of childbearing age were included in the PCOS case group,and female health examination subjects were included in the control group.Serum metabolic and inflammatory markers were compared between the two groups.At the same time,Pearson correlation coefficient was used to analyze the correlation between metabolic and inflammatory markers in PCOS patients.Result:The levels of Ferriman-galway(F-G)score,luteinizing hormone(LH),follicle stimulating hormone(FSH),total testosterone,homeostasis model assessment of insulin resistance(HOMA-IR),fasting plasma insulin(FINS),C reactive protein(CRP),procalcitonin(PCT),tumor necrosis factor-α(TNF-α)and interleukin-6(IL-6)in PCOS cases group were higher than those of control group,the differences were statistically significant(P<0.05).Serum CRP levels in PCOS patients were positively correlated with LH,FSH,HOMA-IR(r=0.897,0.148,0.767,P<0.05),serum TNF-αwas positively correlated with F-G score,FINS,LH,FSH,HOMA-IR(r=0.994,0.402,0.453,0.136,0.399,P<0.05),serum IL-6 level was positively correlated with F-G score,FINS,LH,FSH,TT,HOMA-IR(r=0.253,0.612,0.199,0.202,0.829,0.948,P<0.05).Conclusion:PCOS women of reproductive age have chronic inflammatory and metabolic disorders,and the levels of inflammatory markers are related to metabolic disorders.

关 键 词：多囊卵巢综合征 C反应蛋白 降钙素原 肿瘤坏死因子-α 白细胞介素-6 

分 类 号：R711.75[医药卫生—妇产科学]