不同剂量福辛普利在肾病综合征或IgA肾病患儿中的应用效果对比  

Effect Comparison of Different Doses of Fosinopril in Children with Nephrotic Syndrome or IgA Nephropathy

作　　者：黄木兰 胡芳玉 胡礼涛 HUANG Mulan;HU Fangyu;HU Litao(Pediatrics,Ganzhou Maternal and Child Health Hospital,Ganzhou 341000,China;不详)

机构地区：[1]赣州市妇幼保健院儿科,江西赣州341000

出　　处：《中国医学创新》2024年第33期57-61,共5页Medical Innovation of China

摘　　要：目的:探究不同剂量福辛普利在肾病综合征或免疫球蛋白A(IgA)肾病患儿中的应用效果。方法:选取2018年10月—2023年10月赣州市妇幼保健院收治的80例肾病综合征或IgA肾病患儿作为研究对象,根据治疗方法的不同将其分为A组(常规西药治疗,n=24)、B组[在A组基础上+福辛普利0.1 mg/(kg·d)治疗,n=28]和C组[在A基础上+福辛普利0.3 mg/(kg·d)治疗,n=28]。比较三组血压、血常规[白细胞(WBC)、血红蛋白(Hb)]、肝功能[谷丙转氨酶(ALT)]、24 h尿蛋白定量、尿蛋白转阴率、血肌酐(Scr)、血钾、肌酐清除率(Ccr)及不良事件发生情况。结果:治疗6个月后,A组收缩压、舒张压、平均动脉压与治疗前比较,差异均无统计学意义(P>0.05);治疗6个月后,B组、C组收缩压、舒张压、平均动脉压均低于治疗前及A组,差异均有统计学意义(P<0.05)。治疗前、治疗6个月后,A组、B组、C组WBC、Hb、ALT比较,差异均无统计学意义(P>0.05)。治疗6个月后,C组尿蛋白转阴率高于A组、B组,且B组尿蛋白转阴率高于A组,差异均有统计学意义(P<0.05)。治疗6个月后,三组Scr、血钾比较,差异均有统计学意义(P<0.05);且B组、C组Scr高于A组,C组血钾高于A组,差异均有统计学意义(P<0.05);治疗前、治疗6个月后,三组Ccr比较,差异均无统计学意义(P>0.05)。三组均未出现严重的不良事件,仅C组出现2例轻微头晕,经干预后痊愈。结论:在常规用药的基础上加用福辛普利治疗肾病综合征或IgA肾病患儿的效果更好,而且相比于0.1 mg/(kg·d)剂量福辛普利,采用0.3 mg/(kg·d)剂量福辛普利治疗,对患者尿蛋白转阴率改善效果更明显。Objective:To explore the effect of different doses of Fosinopril in children with nephrotic syndrome or immunoglobulin A(IgA)nephropathy.Method:A total of 80 children with nephrotic syndrome or IgA nephropathy admitted to Ganzhou Maternal and Child Health Hospital from October 2018 to October 2023 were selected as the study objects,and they were divided into group A(conventional western medicine treatment,n=24),group B[on the basis of group A+Fosinopril 0.1 mg/(kg·d)treatment,n=28]and group C[on the basis of A+Fosinopril 0.3 mg/(kg·d)treatment,n=28]according to different treatment methods.Blood pressure,blood routine[white blood cells(WBC),hemoglobin(Hb)],liver function[alanine aminotransferase(ALT)],24 h urinary protein quantification,urine protein negative conversion rate,serum creatinine(Scr),serum potassium,creatinine clearance(Ccr)and adverse events were compared among the three groups.Result:After 6 months of treatment,systolic blood pressure,diastolic blood pressure and mean arterial pressure in group A were not significantly different from those before treatment(P>0.05).After 6 months of treatment,the systolic blood pressure,diastolic blood pressure and average arterial pressure of group B and group C were lower than those before treatment and those of group A,the differences were statistically significant(P<0.05).There were no significant differences in WBC,Hb and ALT in group A,group B and group C before treatment and 6 months after treatment(P>0.05).After 6 months of treatment,the urine protein conversion rate of group C was higher than that of group A and group B,and the urine protein conversion rate of group B was higher than that of group A,the differences were statistically significant(P<0.05).After 6 months of treatment,there were significant differences in Scr and blood potassium among the three groups(P<0.05);Scr in group B and group C was higher than that in group A,and blood potassium in group C was higher than that in group A,the differences were statistically significant(P<0.05).There was

关 键 词：不同剂量 福辛普利 肾病综合征 IGA肾病 患儿 血压 尿蛋白 

分 类 号：R726.9[医药卫生—儿科]