孟鲁司特钠联合双歧杆菌四联活菌治疗儿童腹型过敏性紫癜的效果分析  

Analysis of the Efficacy of Montelukast Sodium Combined with Bifidobacterium,Lactobacillus,Enterococcus and Bacillus Cereus in the Treatment of Children with Abdominal Allergic Purpura

作　　者：张军 屈林林 ZHANG Jun;QU Linlin(Department of Pediatrics,Suqian First People's Hospital,Suqian 223800,China;不详)

机构地区：[1]宿迁市第一人民医院儿科,江苏宿迁223800

出　　处：《中国医学创新》2024年第33期86-90,共5页Medical Innovation of China

摘　　要：目的:探讨孟鲁司特钠联合双歧杆菌四联活菌治疗腹型过敏性紫癜患儿的临床效果。方法:选取2021年5月—2024年5月宿迁市第一人民医院收治的150例腹型过敏性紫癜患儿作为研究对象,采用随机数字表法分为对照组和试验组,各75例。两组同时接受补液、抗过敏、抗血小板聚集等基础治疗,对照组给予孟鲁司特钠治疗,试验组给予孟鲁司特钠+双歧杆菌四联活菌治疗。两组均治疗1个月,观察两组肠道菌群[乳杆菌(LAC)、双歧杆菌(BIF)、肠杆菌(ENT)、肠球菌(EC)]、免疫功能指标[免疫球蛋白A(IgA)、免疫球蛋白G(IgG)、免疫球蛋白M(IgM)]、肾损伤指标[胰岛素样生长因子-1(IGF-1)、可溶性人基质裂解素(sST2)、转化生长因子-β1(TGF-β1)]变化情况,并比较两组治疗总有效率及不良反应发生率。结果:治疗后,试验组LAC、BIF均高于对照组,ENT、EC均低于对照组,差异均有统计学意义(P<0.05)。治疗后,试验组IgA、IgG、IgM水平均低于对照组,差异均有统计学意义(P<0.05)。治疗后,试验组IGF-1、sST2、TGF-β1水平均低于对照组,差异均有统计学意义(P<0.05)。试验组治疗总有效率高于对照组,差异有统计学意义(P<0.05);两组不良反应发生率比较,差异无统计学意义(P>0.05)。结论:针对腹型过敏性紫癜患儿,在基础治疗的同时予以孟鲁司特钠联合双歧杆菌四联活菌治疗,可改善肠道内免疫环境,调节肠道内有益、有害菌群数目,提高治疗效果,且联合方案能减轻肾损伤,不增加不良反应发生率。Objective:To investigate the clinical effect of Montelukast Sodium combined with Bifidobacterium,Lactobacillus,Enterococcus and Bacillus Cereus in the treatment of children with abdominal allergic purpura.Method:A total of 150 children with abdominal allergic purpura treated in Suqian First People's Hospital from May 2021 to May 2024 were selected as the study objects,and they were divided into control group and experimental group by random number table method,with 75 cases in each group.The two groups received liquid rehydration,anti-allergy,anti-platelet aggregation and other basic treatment,the control group was given Montelukast Sodium treatment,the experimental group was given Montelukast Sodium combined with Bifidobacterium,Lactobacillus,Enterococcus and Bacillus Cereus treatment.Both groups were treated for 1 month.The changes of intestinal flora[lactobacillus(LAC),bifidobacterium(BIF),enterobacterium(ENT),enterococcus(EC)],immune function indexes[immunoglobulin A(IgA),immunoglobulin G(IgG),immunoglobulin M(IgM)],kidney injury indexes[insulin-like growth factor-1(IGF-1),soluble human stromal lysin(sST2),transforming growth factor-β1(TGF-β1)]in the two groups were compared,and the total effective rate and incidence of adverse reactions between the two groups were compared.Result:After treatment,LAC and BIF in experimental group were higher than those in control group,ENT and EC were lower than those in control group,the differences were statistically significant(P<0.05).After treatment,the levels of IgA,IgG and IgM in experimental group were lower than those in control group,the differences were statistically significant(P<0.05).After treatment,the levels of IGF-1,sST2 and TGF-β1 in experimental group were lower than those in control group,the differences were statistically significant(P<0.05).The total effective rate of experimental group was higher than that of control group,the difference was statistically significant(P<0.05).There was no significant difference in the incidence of adverse reactions be

关 键 词：儿童腹型过敏性紫癜 孟鲁司特钠 双歧杆菌四联活菌 

分 类 号：R725.5[医药卫生—儿科]