黄疸茵陈颗粒在新生儿黄疸中的应用效果及对血清学指标的影响  

Application Effect of Huangdan Yinchen Granules in Neonatal Jaundice and Its Influence on Serological Indexes

作　　者：郑会来 董晓斐[2] ZHENG Huilai;DONG Xiaofei(Hunan University of Chinese Medicine,Changsha 410208,China;不详)

机构地区：[1]湖南中医药大学,湖南长沙410208 [2]湖南中医药大学第一附属医院新生儿科,湖南长沙410007

出　　处：《中国医学创新》2024年第33期133-136,共4页Medical Innovation of China

摘　　要：目的:探究黄疸茵陈颗粒在新生儿黄疸中的应用效果及对血清学指标的影响。方法:将2021年1月—2024年1月湖南中医药大学第一附属医院收治的120例新生儿黄疸患儿根据随机数字表法分为对照组(n=60)和观察组(n=60)。对照组进行常规治疗,观察组则在对照组的基础上加用黄疸茵陈颗粒。比较两组治疗总有效率、黄疸消退时间、不良反应发生率及血清学指标。结果:观察组治疗总有效率显著高于对照组,黄疸消退时间早于对照组,差异均有统计学意义(P<0.05);两组不良反应总发生率比较,差异无统计学意义(P>0.05);治疗前两组血清学指标比较,差异均无统计学意义(P>0.05);治疗3、5 d后,观察组未结合胆红素、总胆红素、总胆汁酸均显著低于对照组,转铁蛋白及白蛋白均显著高于对照组,差异均有统计学意义(P<0.05)。结论:黄疸茵陈颗粒在新生儿黄疸中的应用效果较好,可显著改善患儿血清学指标,且安全性较高。Objective:To investigate the application effect of Huangdan Yinchen Granules in neonatal jaundice and its influence on serological indexes.Method:A total of 120 children with neonatal jaundice admitted to the First Affiliated Hospital of Hunan University of Chinese Medicine from January 2021 to January 2024 were divided into control group(n=60)and observation group(n=60)according to random number table method.The control group was treated with routine treatment,and the observation group was treated with Huangdan Yinchen Granules on the basis of control group.The total effective rate,jaundice resolution time,incidence of adverse reactions and serological indexes were compared between the two groups.Result:The total effective rate of the observation group was significantly higher than that of the control group,and the jaundice resolution time was earlier than that of the control group,the differences were statistically significant(P<0.05).There was no significant difference in the total incidence of adverse reactions between the two groups(P>0.05).There were no significant differences in serological indexes between the two groups before treatment(P>0.05).After 3 and 5 days of treatment,unconjugated bilirubin,total bilirubin and total bile acid in observation group were significantly lower than those in control group,and transferrin and albumin were significantly higher than those in control group,the differences were statistically significant(P<0.05).Conclusion:The application effect of Huangdan Yinchen Granules in neonatal jaundice is good,which can significantly improve the serological indexes of children and has high safety.

关 键 词：黄疸茵陈颗粒 新生儿黄疸 总胆红素 

分 类 号：R722.17[医药卫生—儿科]