依托考昔联合痹痛汤方对膝骨关节炎患者临床疗效及血清相关水平影响研究  

Study of the etoricoxib combined with Bitong decoction formula on the clinical effect and serum level in patients with knee osteoarthritis

作　　者：李叶舟 唐成剑[1] 陈培 陈青[2] LI Yezhou;TANG Chengjian;CHEN Pei;CHEN Qing(Department of Orthopedics,First Affiliated Hospital of Hunan University of Traditional Chinese Medicine,Changsha 410021,China;Hospital Office,First Affiliated Hospital of Hunan University of Traditional Chinese Medicine,Changsha 410021,China)

机构地区：[1]湖南中医药大学第一附属医院骨科,长沙410021 [2]湖南中医药大学第一附属医院医院办公室,长沙410021

出　　处：《药物流行病学杂志》2024年第11期1201-1208,共8页Chinese Journal of Pharmacoepidemiology

基　　金：湖南创新型省份建设专项项目(2024JJ9424)。

摘　　要：目的探讨依托考昔联合痹痛汤方对膝骨关节炎患者临床疗效及血清相关水平的影响。方法采用回顾性分析方法,收集2022年8月—2023年8月本院收治的膝骨关节炎患者,根据用药方式分为联合组与对照组。对照组给予依托考昔片,联合组在对照组基础上联合痹痛汤方,2组均治疗1个月。比较2组治疗后疗效、中医证候积分、治疗前后膝关节功能[骨性关节炎指数(WOMAC)、Lequesne评分]、炎症因子[白细胞介素-1β(IL-1β)、肿瘤坏死因子-α(TNF-α)、基质金属蛋白酶-3(MMP-3)、金属蛋白酶组织抑制因子-1(TIMP-1)]、氧化应激指标[总抗氧化能力(TAOC)、脂质过氧化物(LPO)、一氧化氮(NO)]及安全性。结果共纳入162例患者,其中联合组和对照组各81例。联合组整体疗效及总有效率高于对照组(P<0.05);治疗后,2组各中医证候积分、WOMAC、Lequesne评分、IL-1β、TNF-α、MMP-3、TIMP-1、LPO、NO水平均较治疗前下降,而TAOC则较治疗前上升(P<0.05);且联合组上述各项指标均优于对照组(P<0.05)。2组安全性相当(P>0.05)。结论依托考昔联合痹痛汤方在膝骨关节炎中疗效优于单一西药,可改善临床症状与膝关节功能,还可减轻炎症及氧化应激,且安全性较高。Objective To explore the effect of etoricoxib combined with Bitong decoction formula on the clinical efficacy and serum level of patients with knee osteoarthritis.Methods Retrospective analysis was used to collect patients with knee osteoarthritis admitted to our hospital from August 2022 to August 2023.According to the medication method,they were divided into the combined group and the control group.The control group was given etoricoxib tablets,and the combination group was given a combination of Bitong decoction formula on the basis of the control group.Both groups were treated for one month.The efficacy after treatment,Traditional Chinese Medicine(TCM)syndrome score,the knee joint function[osteoarthritis index(WOMAC),Lequesne score],inflammatory indicators[interleukin-1β(IL-1β),tumor necrosis factor-α(TNF-α),matrix metalloproteinase-3(MMP-3),tissue inhibitor of metalloproteinase-1(TIMP-1)],oxidative stress indicators[total antioxidant capacity(TAOC),lipid peroxidation(LPO),nitric oxide(NO)]before and after treatment and safety of the two groups were compared.Results A total of 162 patients were included,with 81 in each group.The overall efficacy and total effective rate of the combined group were higher than those of the control group(P<0.05).After treatment,TCM syndrome score,WOMAC,Lequesne score,IL-1β,TNF-α,MMP-3,TIMP-1,LPO and NO levels in two groups were decreased compared with before treatment,while TAOC increased compared with before treatment(P<0.05),and all the above indexes in the combination group were better than those in the control group(P<0.05).The safety of the two groups was comparable(P>0.05).Conclusion The efficacy of etoricoxib combined with Bitong decoction formula in knee osteoarthritis is better than that of single western medicine,which can alleviate symptoms and improve knee joint function,as well as reduce inflammation and oxidative stress,and has high safety.

关 键 词：膝骨关节炎 依托考昔 痹痛汤方 疗效 炎症因子 氧化应激 

分 类 号：R684.3[医药卫生—骨科学]