制何首乌的炮制工艺、化学成分和药理活性研究进展  

Research progress on processing technology,chemical constituents and pharmacological activities of Polygoni multiflori radix praeparata

作　　者：么蕊 郭鸿 张晓书 王莹[1] 郭晓晗 陈佳[1] 李金豪 徐玲 杨建波[1] 荆文光 程显隆[1] 魏锋[1] YAO Rui;GUO Hong;ZHANG Xiaoshu;WANG Ying;GUO Xiaohan;CHEN Jia;LI Jinhao;XU Ling;YANG Jianbo;JING Wenguang;CHENG Xianlong;WEI Feng(National Institutes for Food and Drug Control,Beijing 100050,China;School of Functional Food and Wine,Shenyang Pharmaceutical University,Shenyang 110016,China;College of Chemistry&Pharmacy,Northwest A&F University,Yangling 712100,Shaanxi Province,China;Hubei Institute for Drug control,Wuhan 430075,China)

机构地区：[1]中国食品药品检定研究院,北京100050 [2]沈阳药科大学功能食品与葡萄酒学院,沈阳110016 [3]西北农林科技大学化学与药学院,陕西杨陵712100 [4]湖北省药品监督检验研究院,武汉430075

出　　处：《药学前沿》2024年第11期523-535,共13页China Pharmacist

基　　金：国家药品标准制修订研究课题项目(BZ20230279);国家药监局中药材及饮片质量控制重点实验室科研项目(2024GSMPA-KL01);国家重点研发计划“中医药现代化”重点专项项目(2023YFC3504105);国家药品监督管理局药品监管科学体系建设重点项目(RS2024Z006)。

摘　　要：制何首乌是何首乌Polygonum multiforum Thunb.的炮制加工品,主要成分包括二苯乙烯苷类、蒽醌类、黄酮类、生物碱类、酚酸类等,具有抗氧化、补血、抗肿瘤、降血糖、抗炎等药理作用,临床上使用广泛。炮制工艺主要为黑豆汁炖制、蒸制、九蒸九制和炆制,炮制后颜色加深,成分含量也会发生变化。通过查阅国内外文献,发现对制何首乌的研究相较于何首乌而言不够全面,因此对近20年来报道的制何首乌炮制工艺、化学成分、药理活性的研究进行系统综述,为进一步开发制何首乌提供参考。Polygoni multiflori radix praeparata is a processed product of Polygoni multiflori radix(Polygonum multiflorum Thunb.),and its main components include stilbene glycosides,anthraquinones,flavonoids,alkaloids,phenolic acids,etc.It has antioxidant,antianemic,anti-tumor,hypoglycemic,anti-inflammatory effects,etc,and is widely used in clinical practice.The processing technology is mainly stewinging with black bean juice,steaming,processing for 9 times and braising and simmering.After processing,the color deepens and the content of composition changes.By consulting domestic and foreign literature,the research on Polygoni multiflori radix praeparata is not comprehensive enough compared with Polygoni multiflori radix.Therefore,this paper mainly summarizes the processing technology,chemical composition and pharmacological activity of Polygoni multiflori radix preparata reported in the past 20 years,and provides a reference for further development of Polygoni multiflori radix preparata.

关 键 词：制何首乌 炮制工艺 化学成分 二苯乙烯苷类 蒽醌类 黄酮类 生物碱类 酚酸类 药理活性 抗氧化 补血 抗肿瘤 降血糖 抗炎 

分 类 号：R283[医药卫生—中药学]