清开灵注射液辅助治疗小儿脓毒症毒热证的效果及对炎症因子、心肌受损程度的影响  

Effect of Qingkailing Injection in the adjuvant treatment of children with sepsis of toxic heat syndrome and its influence on inflammatory factors and myocardial damage

作　　者：朱锐 ZHU Rui(Department of Pediatrics,Shuyang Hospital of Traditional Chinese Medicine,Jiangsu Province,Shuyang 223600,China)

机构地区：[1]江苏省沭阳县中医院儿科,江苏沭阳223600

出　　处：《妇儿健康导刊》2024年第22期73-77,共5页JOURNAL OF WOMEN AND CHILDREN'S HEALTH GUIDE

基　　金：江苏省宿迁市指导性科技计划项目(Z2022009)。

摘　　要：目的探讨清开灵注射液辅助治疗小儿脓毒症毒热证的效果及对炎症因子、心肌受损程度的影响。方法选取沭阳县中医院2020年5月至2023年7月收治的60例脓毒症毒热证患儿作回顾性分析,根据不同治疗方案分为对照组(n=30)与观察组(n=30)。对照组采用常规综合治疗,观察组在对照组基础上联合清开灵注射液治疗。比较两组病情程度、炎症因子水平、心肌损伤标志物水平及凝血功能。结果治疗后,观察组小儿危重症评分高于对照组,快速序贯器官衰竭评分、急性生理与慢性健康评分低于对照组(P<0.05)。治疗后,观察组肿瘤坏死因子-α、超敏C反应蛋白、白细胞介素-6水平较对照组低,白细胞介素-10水平较对照组高(P<0.05)。治疗后,观察组N端脑钠肽前体、超敏肌钙蛋白T、肌酸激酶同工酶水平均低于对照组(P<0.05)。治疗后,观察组纤维蛋白原、D-二聚体水平较对照组低,抗凝血酶Ⅲ水平较对照组高(P<0.05)。结论小儿脓毒症毒热证采取清开灵注射液治疗可有效改善患儿病情,降低炎症因子水平及心肌损伤程度,改善凝血功能,可在临床中借鉴使用。Objective To explore the effect of Qingkailing Injection in the adjuvant treatment of children with sepsis of toxic heat syndrome and its influence on inflammatory factors and myocardial damage.Methods A total of 60 children with sepsis of toxic heat syndrome admitted to Shuyang Hospital of Traditional Chinese Medicine from May 2020 to July 2023 were selected for the retrospective analysis.All the children were divided into the control group(n=30)and the observation group(n=30)according to different treatment protocols.The control group was given conventional comprehensive treatment,and the observation group was treated with Qingkailing Injection on the basis of the control group.The severity of disease,inflammatory factor levels,myocardial damage marker levels,and coagulation function were compared between the two groups.Results After treatment,compared with the control group,the pediatric critical illness score of the observation group was higher,quick sequential organ failure assessment and acute physiology and chronic health evaluationⅡscores were lower(P<0.05).After treatment,compared with the control group,the levels of tumor necrosis factor-α,hypersensitive C-reactive protein,and interleukin-6 were lower in the observation group,and the level of interleukin-10 was higher(P<0.05).After treatment,compared with the control group,the levels of N terminal pro brain natriuretic peptide,high-sensitivity cardiac troponin T,and creatine kinase-MB in the observation group were lower(P<0.05).After treatment,the fibrinogen and D-dimer levels in the observation group were lower and the antithrombinⅢlevel was higher than those in the control group(P<0.05).Conclusion Qingkailing Injection for the treatment of children with sepsis of toxic heat syndrome can effectively improve the condition of children,reduce the levels of inflammatory factors and the degree of myocardial damage,and improve coagulation function,which can be used for reference in clinical practice.

关 键 词：清开灵注射液 小儿脓毒症 毒热证 炎症因子 心肌损伤 凝血功能 

分 类 号：R720.597[医药卫生—急诊医学]