Recent advances of aggregation-induced emission in body surface organs  

作　　者：Hang Li Tingting Zhang Yingying Liao Chutong Liu Yisheng He Yongfei Wang Conglei Li Cheng Jiang Chenzhong Li Guanghong Luo Zhongyuan Xiang Yanhong Duo 

机构地区：[1]Department of Laboratory Medicine,The Second Xiangya Hospital,Central South University,Changsha,China [2]Department of Pharmacy,The Second Xiangya Hospital,Central South University,Changsha,China [3]The Eighth Affiliated Hospital,Sun Yat-sen University,Shenzhen,China [4]School of Medicine,The Chinese University of Hong Kong(Shenzhen),Shenzhen,China [5]Department of Radiation Oncology,Shenzhen People’s Hospital(The Second Clinical Medical College,The First Affiliated Hospital,Jinan University,Southern University of Science and Technology),Shenzhen,China [6]Wyss Institute for Biologically Inspired Engineering,School of Engineering and Applied Science,Harvard University,Boston,Massachusetts,USA

出　　处：《Aggregate》2024年第2期61-81,共21页聚集体（英文）

基　　金：National Natural Science Foundation of China,Grant/Award Number:82102904;the Science,Technology&Innovation Commission of Shenzhen Municipality,Grant/Award Number:JCYJ20210324113405014;Hunan Provincial Science and Technology Plan Project,Grant/Award Number:2021SK5001;Natural Science and Health Bureau of Hunan Province,Grant/Award Number:2021JJ70136。

摘　　要：The surface organs mainly comprise the superficial layers of various parts of the mammalian body,including the skin,eyes,and ears,which provide solid protection against various threats to the entire body.Damage to surface organs could lead to many serious diseases or even death.Currently,despite significant advancements in this field,there remain numerous enigmas that necessitate expeditious resolution,particularly pertaining to diagnostic and therapeutic objectives.The advancements in nanomedicine have provided a significant impetus for the development of novel approaches in the diagnosis,bioimaging,and therapy of superficial organs.The aggregation-induced emission(AIE)phenomenon,initially observed by Prof.Ben Zhong Tang,stands out due to its contrasting behavior to the aggregationcaused quenching effect.This discovery has significantly revolutionized the field of nanomedicine for surface organs owing to its remarkable advantages.In this review of literature,we aim to provide a comprehensive summary of recent advances of AIE lumenogen(AIEgen)-based nanoplatforms in the fields of detection,diagnosis,imaging,and therapeutics of surface organ-related diseases and discuss their prospects in the domain.It is hoped that this review will help attract researchers’attention toward the utilization of this field for the exploration of a wider range of biomedical and clinical applications.

关 键 词：aggregation-induced emission BIOIMAGING DIAGNOSIS surface organ THERAPY 

分 类 号：TB34[一般工业技术—材料科学与工程]