Rearranging fluorescence-magneto spatiality for“win-win”dual functions to enhance point-of-care diagnosis  

作　　者：Yu Su Xirui Chen Huan Huang YuhaoWu Xuan-ang Shen Xiangkai Lin Kun Sun Xiao-Yong Fan Xiaolin Huang Yonghua Xiong 

机构地区：[1]State Key Laboratory of Food Science and Resources,Nanchang University,Nanchang,P.R.China [2]School of Food Science and Technology,Nanchang University,Nanchang,P.R.China [3]Shanghai Institute of Infectious Disease and Biosecurity,Shanghai Public Health Clinical Center,Fudan University,Shanghai,China [4]Shanghai Key Laboratory of Atmospheric Particle Pollution Prevention,Department of Environmental Science and Engineering,Fudan University,Shanghai,China [5]Jiangxi-OAI Joint Research Institute,Nanchang University,Nanchang,P.R.China

出　　处：《Aggregate》2024年第2期357-369,共13页聚集体（英文）

基　　金：National Natural Science Foundation of China,Grant/Award Numbers:32172296,32160598,82171815;Key Research and Development Program of Jiangxi Province,Grant/Award Numbers:20232BBG70030,20232BCD44004;Jiangxi Provincial Natural Science Foundation,Grant/Award Numbers:20224BAB215040,20224ACB205012,20192BAB204021,20202BAB216021;Technological Planning Project of Jiangxi Provincial Health Commission,Grant/Award Numbers:202310455,20201034;Preferential Funding for Scientific Research Projects of Postdoctoral Researchers in Jiangxi Province,Shanghai Hygiene and Health Outstanding Leader Project,Grant/Award Number:2022XD060;Shanghai Science and Technology Commission,Grant/Award Number:20Y11903400;State Key Laboratory of Analytical Chemistry for Life Science,Grant/Award Number:SKLACLS2304。

摘　　要：Fluorescent-magneto nanoemitters have gained considerable attention for their applications in mechanical controlling-assisted optical signaling.However,the incompatibility between magnetic and fluorescent components often leads to functional limitations in traditional magneto@fluorescence nanostructure.Herein,we introduce a new compact-discrete spatial arrangement on a“fluorescence@magneto”core-shell nanostructure consisting of a close-packed aggregation-induced emission luminogen(AIEgen)core and a discrete magnetic shell.This structural design effectively eliminates the optical and magnetic interferences between the dual components by facilitating AIEgens loading in core region and reducing the magnetic feeding amount through effective exposure of the magnetic units.Thereby,the resulting magneto-AIEgen nanoparticle(MANP)demonstrates“win-win”performances:(i)high fluorescent intensity contributed by AIEgens stacking-enhanced photoluminescence and reduced photons loss from the meager magnetic shell;(ii)marked magnetic activity due to magneto extrapositionminimized magnetic shielding.Accordingly,the dual functions-retained MANP provides a proof of concept for construction of an immunochromatographic sensing platform,where it enables bright fluorescent labeling after magnetically enriching and separating procalcitonin and lipoarabinomannan in clinical human serum and urine,respectively,for the clinical diagnosis of bacterial infections-caused inflammation and tuberculosis.This study not only inspires the rational design of magnetic-fluorescent nanoemitter but also highlights promising potential in magneto-assisted point-of-care test and biomedicine applications.

关 键 词：aggregation-induced emission bacterial infection diagnosis fluorescent-magneto nanoemitters point-ofcare diagnosis self-assembly 

分 类 号：O657.3[理学—分析化学]