Helminth-derived molecules: Pathogenic and pharmacopeial roles  

作　　者：Yu Zhang Chunxiang Shen Xinyi Zhu Chiuan Yee Leow Minjun Ji Zhipeng Xu 

机构地区：[1]State Key Laboratory of Reproductive Medicine and Offspring Health,Department of Pathogen Biology,National Vaccine Innovation Platform,Nanjing Medical University,Nanjing,Jiangsu 211166,China [2]School of Pharmaceutical Sciences,Universiti Sains Malaysia,Minden,Penang 11800,Malaysia [3]NHC Key Laboratory of Antibody Technique,Nanjing Medical University,Nanjing,Jiangsu 211166,China

出　　处：《Journal of Biomedical Research》2024年第6期547-568,共22页生物医学研究杂志（英文版）

基　　金：supported by the National Natural Science Foundation of China(Z.P.X,Grant No.82472311);the Natural Science Foundation of Jiangsu Province(Z.P.X,Grant No.BK20211586);the Funding of the State Key Laboratory of Reproductive Medicine(Z.P.X,Grant Nos.SKLRM-2021C3 and SKLRM-2024B14);the Medical Scientific Research Project of Jiangsu Provincial Health Commission(Z.P.X,Grant No.Z2021004);the National Sharing Service Platform for Parasite Resources(Z.P.X,Grant No.TDRC-2019-194-30);the Qing Lan Project of Jiangsu Province of China(Z.P.X,Grant No.KY101R202127).

摘　　要：Parasitic helminths,taxonomically comprising trematodes,cestodes,and nematodes,are multicellular invertebrates widely disseminated in nature and have afflicted humans continuously for a long time.Helminths play potent roles in the host by generating a variety of novel molecules,including some excretory/secretory products and others that are involved in intracellular material exchange and information transfer as well as the initiation or stimulation of immune and metabolic activation.The helminth-derived molecules have developed powerful and diverse immunosuppressive effects to achieve immune evasion for parasite survival and establish chronic infections.However,they also improve autoimmune and allergic inflammatory responses and promote metabolic homeostasis by promoting metabolic reprogramming of various immune functions,and then inducing alternatively activated macrophages,T helper 2 cells,and regulatory T cell-mediated immune responses.Therefore,a deeper exploration of the immunopathogenic mechanism and immune regulatory mechanisms of helminth-derived molecules exerted in the host is crucial for understanding host-helminth interactions,as well as the development of therapeutic drugs for infectious or non-infectious diseases.In this review,we focus on the properties of helminth-derived molecules to give an overview of the most recent scientific knowledge about their pathogenic and pharmacopeial roles in immune-metabolic homeostasis.

关 键 词：HELMINTH helminth-derived molecules immunity metabolism excretory/secretory products extracellular vesicles 

分 类 号：R532[医药卫生—内科学]