服药信念在缺血性心血管病患者疾病感知与二级预防用药依从性间的中介效应分析  

An analysis of the mediating effect of medication beliefs on disease perception and secondary prevention medication adherence in patients with ischemic cardiovascular disease

作　　者：吴晓玲 崔晓燕[1] WU Xiaoling;CUI Xiaoyan(Pharmacy Department,the Fifth People s Hospital of Fuyang City,Fuyang 236600,China)

机构地区：[1]阜阳市第五人民医院药剂科,安徽阜阳236600

出　　处：《现代医学》2024年第11期1715-1720,共6页Modern Medical Journal

摘　　要：目的:了解缺血性心血管病(ICVD)患者服药信念、疾病感知、二级预防用药依从性现状,并分析前者在后两者之间的中介效应。方法:采用服药信念特异性问卷、疾病感知问卷简化版和Morisky服药依从性问卷对210例缺血性心血管病患者进行测评。采用Pearson分析二级预防用药依从性与疾病感知、服药信念之间的相关性,并通过构建结构方程模型(SEM)进行中介效应检验。结果:210例ICVD患者二级预防用药依从性评分(5.08±0.42)分、疾病感知评分(43.58±5.24)分、服药信念评分(2.61±0.42)分。二级预防用药依从性与疾病感知、服药信念之间均呈正相关(P<0.05),疾病感知与服药信念之间呈正相关(P<0.05)。服药信念在疾病感知与二级预防用药依从性之间具有27.92%的中介效应。结论:服药信念在疾病感知与二级预防用药依从性之间的中介效应成立,证实ICVD患者疾病感知可以通过服药信念间接影响用药依从性。Objective:To understand patients medication beliefs,disease perceptions,and medication adherence for secondary prevention in ischemic cardiovascular disease(ICVD)patients,and analyze the mediating effect of the former on the latter two.Methods:The medication adherence was assessed using the Medication Belief Scale,Simplified Disease Perceptions Questionnaire,and Morisky Medication Adherence Scale in 210 patients with ischemic cardiovascular disease.Employ Pearson s analysis to examine the correlation between medication adherence for secondary prevention and disease perception,medication belief,and further test the mediating effect through structural equation modeling.Results:The medication adherence score(5.08±0.42),disease perception score(43.58±5.24),and medication belief score(2.61±0.42)for the 210 ICVD patients in the secondary prevention were recorded.Adherence to secondary prevention medications was positively associated with disease perception and medication belief(P<0.05),and disease perception was positively associated with medication belief(P<0.05).Perceived medication beliefs mediated the relationship between illness perception and medication adherence for secondary prevention by 27.92%.Conclusion:The mediating effect of medication beliefs on medication adherence for disease perception and secondary prevention in patients with ICVD is established,confirming that disease perception in these patients can indirectly influence medication adherence through medication beliefs.

关 键 词：缺血性心血管病 二级预防用药依从性 疾病感知 服药信念 中介效应 

分 类 号：R969.3[医药卫生—药理学]