孕前体质指数对胎儿先天性心脏病影响及疾病谱分析  

Analysis of maternal body mass index and fetal congenital heart disease spectrum

作　　者：王晨雨 阮燕萍[1] 谷孝艳[1] 郝晓艳[1] 张烨[1] 赵映[1] 何怡华[1] WANG Chenyu;RUAN Yanping;GU Xiaoyan;HAO Xiaoyan;ZHANG Ye;ZHAO Ying;HE Yihua(Echocardiography Medical Center,Beijing Anzhen Hospital,Capital Medical University,Maternal-Fetal Medicine Center in Fetal Heart Disease,Beijing Anzhen Hospital,Capital Medical University,Beijing Institute of Heart,Lung and Blood Vessel Diseases,100029 Beijing,China)

机构地区：[1]首都医科大学附属北京安贞医院心脏-北京市心肺血管疾病研究所,北京安贞医院胎儿心脏病母胎医学中心心脏超声医学中心,100029

出　　处：《心肺血管病杂志》2024年第11期1190-1195,共6页Journal of Cardiovascular and Pulmonary Diseases

基　　金：国家自然科学基金(U21A20523);国家自然科学基金面上项目(82170301)。

摘　　要：目的:分析孕前BMI水平与胎儿患先天性心脏病(congenital heart disease,CHD)疾病谱差异及变化趋势,以期为孕前及孕期体质量管理重要性及必要性提供依据。方法:纳入2020年1月至2022年12月,于首都医科大学附属北京安贞医院行胎儿超声心动图检查的孕妇,根据纳入及排除标准最终纳入6858例,根据孕前BMI分为正常体质量组(18.5≤BMI<24.0kg/m^(2)),超质量组(24.0≤BMI<28.0kg/m^(2))及肥胖组(BMI≥28.0 kg/m^(2)),分析不同亚组其胎儿患CHD疾病谱差异及变化趋势。结果:随着孕前BMI水平升高,胎儿患CHD比例升高。在不同亚组中,胎儿先天性心脏病疾病谱存在一定差异,在肥胖组中,单纯性室间隔缺损比例升高,而永存左上腔静脉比例明显低于正常体质量组。结论:孕前不同BMI水平其胎儿患CHD疾病谱及变化趋势存在差异,为孕前及孕期体质量管理重要性及必要性提供依据。Objective:To analyze the differences and changing trends between maternal body mass index(BMI)levels and fetal congenital heart disease(CHD)disease spectrum,to provide a basis for the importance and necessity of weight management before and during pregnancy.Methods:According to the inclusion and exclusion criteria,6858 pregnant women who underwent fetal echocardiography at Beijing Anzhen Hospital Affiliated to Capital Medical University from January 2020 to December 2022 were included.They were divided into a normal group(18.5≤BMI<24.0kg/m^(2)),the overweight group(24.0≤BMI<28.0kg/m^(2)),and the obese group(BMI≥28.0kg/m^(2))according to different BMI levels.The differences and changing fetal CHD disease spectrum trends in different subgroups were analyzed.Results:With the increase in BMI level,the proportion of fetal CHD increased.The spectrum of fetal congenital heart disease was different in different subgroups.In the obese group,the proportion of ventricular septal defects was significantly increased.In contrast,the proportion of persistent left superior vena cava was substantially lower than that in the normal weight group.Conclusion:The spectrum of fetal CHD and its changing trend is different in pregnant women with different BMI levels,which provides a basis for the importance and necessity of weight management before and during pregnancy.

关 键 词：先天性心脏病 肥胖 体质指数 胎儿 

分 类 号：R54[医药卫生—心血管疾病]