生物源性钙磷灰石尺寸引发的骨仿生层级演变及其骨凝血免疫效应  

Hierarchical evolution of bone biomimicry and osteo-coagulo-immunomodulation induced by the size of biological hydroxyapatite

作　　者：许洁芸 赵原 刘浩州 尹靖元 陈泽涛 Xu Jieyun;Zhao Yuan;Liu Haozhou;Yin Jingyuan;Chen Zetao(Hospital of Stomatology,Sun Yat-sen University&Guangdong Provincial Key Laboratory of Stomatology,Guangzhou 510055,China)

机构地区：[1]中山大学附属口腔医院,广东省口腔医学重点实验室,广州510055

出　　处：《华西口腔医学杂志》2024年第6期706-715,共10页West China Journal of Stomatology

基　　金：广东省科技计划项目(2023A0505050138);国家自然科学基金面上项目(82071167);广州市科技计划项目(2024A04-J6323);国家资助博士后研究人员计划(GZC20233280)。

摘　　要：生物源性钙磷灰石(BHA)因良好的生物相容性和骨传导性,广泛应用于临床骨缺损的治疗中。基于临床应用中的骨缺损区适配原则,BHA具有尺寸多元性设计,然而不同尺寸对应着不同的骨仿生层级,随着尺寸变化,其具备的骨仿生层级随之演变,并通过骨凝血免疫调控影响骨修复再生进程,导致植骨结局不稳定。本文对BHA的尺寸效应进行回顾,通过分析天然骨多级结构,提出BHA尺寸引发骨仿生层级演变,仿生层级介导凝血免疫效应,并基于骨仿生层级及其骨凝血免疫效应,提出对不同尺寸BHA材料生物学效应的新认识及其生物学原理,为不同尺寸BHA材料的基础研发和临床应用提供理论基础。Biological hydroxyapatite(BHA)is widely used in the treatment of clinical bone defects due to its good biocompatibility and osteoconductivity.The clinical application of mateiral size is based on the principle of bone defect area adaptation,which contributes to diversity of BHA sizes.However,different sizes correspond to different hierarchical levels of bone biomimicry.As the size changes,the bone biomimicry hierarchy evolves accordingly and influences the process of bone repair and regeneration through osteo-coagulo-immunomodulation,leading to unstable bone graft outcomes.Therefore,this paper reviews the size effect of clinical BHA,analyzes the multilevel structure of natural bone,proposes the evolution of bone biomimetic hierarchy triggered by the size of BHA,and further analyzes the size-media-ted osteo-coagulo-immunomodulation.Based on the hierarchical levels of bone and its osteo-coagulo-immunomodulation effect,we provide a new understanding of the biological principle of the size effect of biomaterials and a theoretical basis for the basic research and clinical application of different size BHA materials.

关 键 词：生物源性钙磷灰石 仿生层级演变 骨凝血免疫 材料尺寸效应 

分 类 号：R318.08[医药卫生—生物医学工程]