血浆前清蛋白对老年新冠肺炎病人并发呼吸衰竭影响  

Effect of plasma prealbumin on respiratory failure in elderly patients with coronavirus disease 2019

作　　者：王一凡 胡松[1] 于瑶[1] 毛拥军[1] WANG Yifan;HU Song;YU Yao;MAO Yongjun(Department of Geriatric Medicine,The Affiliated Hospital of Qingdao University,Qingdao 266000,China)

机构地区：[1]青岛大学附属医院老年医学科,山东青岛266000

出　　处：《青岛大学学报（医学版）》2024年第5期701-704,共4页Journal of Qingdao University(Medical Sciences)

基　　金：中央引导地方科技发展专项计划项目(21-1-2-2-zyyd-nsh)。

摘　　要：目的探讨血浆前清蛋白(PAB)对老年新型冠状病毒肺炎(简称新冠肺炎)病人并发呼吸衰竭的影响。方法采用横断面研究法,收集2022年12月-2023年1月入院的175例老年新冠肺炎病人的临床资料,根据入院时是否发生呼吸衰竭将病人分为呼吸衰竭组(呼衰组)和正常组,采用多因素Logistic回归分析法分析老年新冠肺炎病人并发呼吸衰竭的影响因素。结果与正常组相比,呼衰组的舒张压、PAB、血红蛋白、体质量指数、清蛋白、预后营养指数、血小板计数和淋巴细胞计数均降低,差异具有统计学意义(t=2.09~3.05,Z=-3.24~-2.01,P<0.05);而呼衰组的女性病人比例、C反应蛋白和降钙素原显著增高,差异具有统计学意义(χ^(2)=2.65,Z=-2.77、-2.72,P<0.05)。多因素Logistic回归分析显示,低PAB(OR=0.892)、女性(OR=3.304)和高C反应蛋白(OR=1.011)是老年新冠肺炎病人并发呼吸衰竭的独立危险因素。结论血浆PAB可作为老年新冠肺炎病人并发呼吸衰竭的潜在预测指标,有助于识别可能并发呼吸衰竭的老年新冠肺炎病人。Objective To investigate the effect of plasma prealbumin(PAB)on respiratory failure in elderly patients with coronavirus disease 2019(COVID-19).Methods In this cross-sectional study,clinical data were collected from 175 elderly patients with COVID-19 who were admitted from December 2022 to January 2023,and according to the presence or absence of respi-ratory failure on admission,the patients were divided into respiratory failure group and normal group.The multivariate Logistic regression analysis was used to investigate the influencing factors for respiratory failure in elderly patients with COVID-19.Results Compared with the normal group,the respiratory failure group had significant reductions in diastolic blood pressure,PAB,hemoglobin,body massindex,albumin,prognostic nutrition index,platelet count,and lymphocyte count(t=2.09-3.05,Z=-3.24 to-2.01,P<0.05)and significant increases in the proportion of female patients and the levels of C-reactive protein(CRP)and procalcitonin(χ^(2)=2.65,Z=-2.77,-2.72,P<0.05).The multivariate Logistic regression analysis showed that low PAB(OR=0.892),female sex(OR=3.304),and high CRP(OR=1.011)were independent risk factors for respiratory failure in elderly patients with COVID-19.Conclusion Plasma PAB can be used as a potential predictive factor for respiratory failure in elderly patients with COVID-19 and may help to identify the elderly patients with COVID-19 who might experience the complication of respiratory failure.

关 键 词：前清蛋白 老年人 新型冠状病毒感染 呼吸功能不全 C反应蛋白质 危险因素 

分 类 号：R563.12[医药卫生—呼吸系统]