2011-2020年天津市健康人群柯萨奇病毒A16型血清中和抗体动态变化研究  

Dynamic change of neutralizing antibody against CVA16 in healthy people living in Tianjin,2011-2020

作　　者：李佳萌[1] 吕莉琨[2] 谭昭麟 张颖[3] Li Jiameng;Lyu Likun;Tan Zhaolin;Zhang Ying(Office of Public Health Emergency,Tianjin Center for Disease Control and Prevention,Tianjin 300011,China;Institute for Pathogen Detection,Tianjin Center for Disease Control and Prevention,Tianjin 300011,China;Director's Office,Tianjin Center for Disease Control and Prevention,Tianjin 300011,China)

机构地区：[1]天津市疾病预防控制中心突发公共卫生事件应急办公室,300011 [2]天津市疾病预防控制中心微生物检验检测所,300011 [3]天津市疾病预防控制中心办公室,300011

出　　处：《国际病毒学杂志》2024年第5期381-385,共5页International Journal of Virology

基　　金：国家科技重大专项(2017ZX10103007);天津市医学重点学科项目(TJYXZDXK-50A);公共卫生人才培养支持项目。

摘　　要：目的 了解天津市健康人群CVA16中和抗体动态变化,为防控手足口病提供依据.方法 采集7 934名天津市健康人的血清进行CVA16中和抗体测定,对检测结果进行分析.结果 CVA16中和抗体阳性率为84.04%,0~5岁年龄组的抗体阳性率最低为65.58%.不同年份间的抗体阳性率有统计学意义;不同区域间、不同年龄组的抗体阳性率均有统计学意义;不同年龄组的抗体滴度有统计学意义,其中5岁及以下年龄的儿童抗体滴度仅0~0.5岁年龄组与其他年龄组抗体滴度有统计学意义.以健康人群CVA16中和抗体阳性率作为应变量,对健康人群的年龄及环境等进行Logistic回归分析,发现半年内去医院和年龄增长是感染CVA16的危险性因素.CVA16中和抗体阳性率与病原阳性率呈负相关关系,第一年的抗体阳性率高第二年的CVA16病原阳性率则低.结论 5岁及以下儿童和流动人口较多地区应作为手足口病防控的重点,CVA16抗体阳性率可以做为估测CVA16流行趋势的依据.Objective To explore the dynamic change of neutralizing antibody against coxsackievirus A16(CVA16)among healthy people in Tianjin,so as to provide a scientific foundation for the prevention and control of hand,foot,and mouth disease(HFMD).Methods A total of 7934 serum samples were collected from healthy people in Tianjin and tested for neutralizing antibody against CVA16.The results were subsequently analyzed.Results The positive rate of CVA16 neutralizing antibody was 84.04%.The lowest positive rate was 65.58%in the 0-5 years old group.The differences in positive rates among various regions and age groups were statistical significant.The differences of antibody titer among age groups were statistical significance.Among the age groups of 5 years old and under,the differences antibody titers between 0-0.5 year old group and other groups were statistical significant.Logistic regression analysis revealed the hospital visit and age were risk factors of CVA16 infection,using the positive rate of CVA16 as the independent variable with age and environments as the dependent variables.The positive rate of CVA16 neutralizing antibody was negatively correlated to the positive rate of the pathogen.Higher annual antibody positive rate was followed by lower positive rate of the pathogen in the next year.Conclusions Children under 5 years old and areas with more mobile population should be focused for the prevention and control of HFMD.The positive rate of CVA16 neutralizing antibody can be used as a possible predictor for the epidemic trend of CVA16.

关 键 词：CVA16 中和抗体 健康人群 动态变化 

分 类 号：R373[医药卫生—病原生物学]