中药干预NLR P3炎性小体防治炎症性关节炎的研究进展  

Research progress of NLR P3 inflammasome in inflammatory arthritis

作　　者：谢宇涵 黄程程 阮文秀 李洋[2] XIE Yu-han;HUANG Cheng-cheng;RUAN Wen-xiu;LI Yang(College of Traditional Chinese Medicine,Shandong University of Traditional Chines Medicine,Jinan,Shandong,250014,China)

机构地区：[1]山东中医药大学中医学院,济南250014 [2]山东中医药大学第二附属医院骨科,济南250014 [3]山东中医药大学第一临床医学院,济南250014 [4]蓬莱区疾病预防控制中心地方病与慢性病防治科,烟台265600

出　　处：《中国骨与关节杂志》2024年第11期950-954,共5页Chinese Journal of Bone and Joint

基　　金：山东省中医药科技项目(M-2023143)。

摘　　要：炎症性关节炎是指由炎症、感染、创伤或其它因素引起的发生在人体关节和周围组织的炎症性疾病。它们有许多共同特征,包括肿胀、疼痛、功能障碍和关节畸形,严重时会导致残疾并影响患者的生活质量[1]。除类风湿性关节炎(rheumatoid arthritis,RA)之外,其它常见的炎症性关节炎还包括骨关节炎(osteoarthritis,OA)、痛风关节炎(gouty arthritis,GA)和强直性脊柱炎(ankylosing spondylitis,AS)等。As an intracellular pattern recognition receptor,the NLR P3 inflammasome is an important part of the innate immune system and plays an essential role in the infiammatory response.Rheumatoid arthritis,osteoarthritis,gouty arthritis,and ankylosing spondylitis are the most common inflammatory arthritis in the clinic,and all of which can lead to joint pain,swelling,and dysfunction that seriously affect patients'quality of life.Targeted regulation of NLR P3 inflammasome activation is essential for the treatment of different types of arthritis.At present,a large number of studies have proved that traditional Chinese medicine and traditional Chinese medicine monomer have significant efficacy and advantages in the treatment of inflammatory arthritis.Traditional Chinese medicine can alleviate joint inflammation and relieve joint pain by targeting and regulating the activation of NLR P3 inflammasome.Therefore,this paper takes the NLR P3 inflammasome as the starting point to analyze the relationship between the occurrence and development of NLR P3 inflammasome in several inflammatory arthritis diseases,and summarize the latest research reports on the targeted regulation of NLR P3 inflammasome in the treatment of inflammatory arthritis by traditional Chinese medicine,providing theoretical basis for the prevention and treatment of infammatory arthritis by traditional Chinesemedicine.

关 键 词：NLR家族 热蛋白结构域包含蛋白3 中医药疗法 关节炎 类风湿 骨关节炎 综述 

分 类 号：R684.3[医药卫生—骨科学]