贝前列素钠联合尿毒清颗粒对维持性血液透析患者睡眠质量及残存肾功能的影响  

Effect of Beraprost Sodium Combined with Niaoduqing Granules on Sleep Quality and Residual Renal Function in Maintenance Hemodialysis Patients

作　　者：庄千迎 ZHANG Qianying(Department of Nephrology,Xiapu County Hospital,Ningde 355100,China)

机构地区：[1]福建省霞浦县医院肾内科,宁德355100

出　　处：《世界睡眠医学杂志》2024年第9期1937-1940,共4页World Journal of Sleep Medicine

摘　　要：目的:探究贝前列素钠联合尿毒清颗粒对维持性血液透析患者睡眠质量及残存肾功能(RRF)的影响。方法:选取2022年3月至2023年3月福建省霞浦县医院肾内科收治的维持性血液透析患者102例作为研究对象,按照随机数字表法分为观察组和对照组,每组51例。对照组给予贝前列素钠治疗,观察组在对照组基础上加尿毒清颗粒治疗,均连续用药2个月。比较2组治疗前后匹兹堡睡眠质量指数(PSQI)量表评分及血尿酸(UA)、RRF、尿素氮(BUN)水平。统计2组总有效率及不良反应发生率。结果:治疗后,2组PSQI评分均较本组治疗前降低(P<0.05),且观察组明显低于对照组(P<0.05)。治疗后,2组血UA、BUN水平均较本组治疗前降低,RRF均较本组治疗前升高,且观察组血UA、BUN水平均低于对照组,RRF高于对照组,差异均有统计学意义(均P<0.05)。观察组总有效率94.12%(48/51),对照组总有效率80.39%(41/51),观察组总有效率高于对照组(P<0.05)。2组不良反应发生率比较差异无统计学意义(P>0.05)。结论:贝前列素钠联合尿毒清颗粒治疗维持性血液透析患者,能够改善患者睡眠质量,保护RRF,安全有效。Objective:To explore the effect of beraprost sodium combined with Niaoduqing Granules on sleep quality and residual renal function(RRF)in maintenance hemodialysis patients.Methods:A total of 102 maintenance hemodialysis patients,admitted to the hospital from March 2022 to March 2023,were randomly divided into control group(51 patients)and observation group(51 patients).The control group was treated with beraprost sodium,while the observation group received additional Niaoduqing Granules alongside beraprost sodium.Pittsburgh Sleep Quality Index(PSQI)scores,blood uric acid(UA),residual renal function(RRF),blood urea nitrogen(BUN)and adverse effects were compared before and after treatment,Results:After treatment,both groups showed significant reductions in PSQI scores compared to pre-treatment levels(P<0.05),with the observation group showing significantly lower scores than the control group(P<0.05).Blood UA and BUN levels in both groups decreased after treatment,while RRF increased(P<0.05).Additionally,the observation group had lower UA and BUN levels and higher RRF than the control group(P<0.05).The total effective rate was significantly higher in the observation group(94.12%,48/51)compared to the control group(80.39%,41/51)(P<0.05).There was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusion:The combination of beraprost sodium with Niaoduqing granules can improve sleep quality and protect RRF in maintenance hemodialysis patients,with a high safety and efficacy profile.

关 键 词：肾透析 贝前列素钠 尿毒清颗粒 残存肾功能 尿素氮 睡眠质量 

分 类 号：R459.52[医药卫生—治疗学] R283.627[医药卫生—临床医学]