右美托咪定联合缺血预处理对心脏疾病非心脏手术患者主观睡眠质量及多导睡眠监测的影响  

Effects of Dexmedetomidine Combined with Ischemic Preconditioning on Subjective Sleep Quality and Polysomnography in Patients with Cardiac Disease Undergoing Non-cardiac Surgery

作　　者：王海振 刘洋[1] 贾佳 WANG Haizhen;LIU Yang;JIA Jia(First Affiliated Hospital of Xiamen University,Xiamen 361000,China)

机构地区：[1]厦门大学附属第一医院,厦门361000

出　　处：《世界睡眠医学杂志》2024年第9期1951-1953,共3页World Journal of Sleep Medicine

摘　　要：目的:分析心脏疾病非心脏手术接受右美托咪定联合缺血预处理对睡眠改善作用。方法:选取2023年2月至2024年2月厦门大学附属第一医院行非心脏手术的心脏疾病患者86例作为研究对象,按照入院次序随机分为对照组和观察组,每组43例。全部患者术中采取静吸复合全身麻醉,对照组提供生理盐水,观察组提供右美托咪定联合缺血预处理。对比2组术后心肾不良反应、多导睡眠监测参数、主观睡眠质量。结果:对比术后心肾不良反应,观察组总发生率相较对照组有大幅下降(P<0.05)。对比组内干预前,2组患者干预后总睡眠时长(TST)明显增加,睡眠潜伏期(SL)、觉醒时间(AT)、觉醒次数(NWAK)明显减少(P<0.05);且观察组上述指标较对照组有更明显改善(P<0.05)。对比组内干预前,2组患者干预后匹兹堡睡眠质量指数(PSQI)明显减少(P<0.05),且观察组上述指标较对照组有更明显改善(P<0.05)。结论:心脏疾病非心脏手术接受右美托咪定联合缺血预处理可减少患者术后不良反应,有助于睡眠状况改善。Objective:To analyze the sleep improvement effect of dexmedetomidine combined with ischemic preconditioning in patients with cardiac disease undergoing non-cardiac surgery.Methods:A total of 86 patients with cardiac disease undergoing non-cardiac surgery at First Affiliated Hospital of Xiamen University from February 2023 to February 2024 were selected for this study.The patients were randomly divided into a control group and an observation group,with 43 patients in each group based on their order of admission.All patients received combined intravenous and inhalation general anesthesia during surgery.The control group was given saline,while the observation group received dexmedetomidine combined with ischemic preconditioning.The incidence of postoperative cardiac and renal adverse events,polysomnography parameters,and subjective sleep quality were compared between the two groups.Results:The incidence of postoperative cardiac and renal adverse events was significantly lower in the observation group compared to the control group(P<0.05).After intervention,the total sleep time(TST)increased significantly,while sleep latency(SL),awake time(AT),and number of awakenings(NWAK)significantly decreased in both groups compared to pre-intervention levels(P<0.05).Moreover,these improvements were more pronounced in the observation group compared to the control group(P<0.05).Pittsburgh Sleep Quality Index(PSQI)scores significantly decreased in both groups after intervention(P<0.05),with the observation group showing greater improvements compared to the control group(P<0.05).Conclusion:Dexmedetomidine combined with ischemic preconditioning in patients with cardiac disease undergoing non-cardiac surgery reduces postoperative adverse events and helps improve sleep quality.

关 键 词：心脏疾病 非心脏手术 右美托咪定 缺血预处理 不良反应 睡眠质量 多导睡眠监测 睡眠障碍 

分 类 号：R338.63[医药卫生—人体生理学]