替勃龙与芬吗通对围绝经期患者睡眠的影响  

Effects of Tibolone and Estradiol/dydrogesterone on Sleep in Perimenopausal Patients

作　　者：叶翠容 罗秀芳 严理莲 YE Cuirong;LUO Xiufang;YAN Lilian(Nanping Pucheng Maternal and Child Health Hospital,Nanping 353400,China)

机构地区：[1]南平市浦城妇幼保健院,南平353400

出　　处：《世界睡眠医学杂志》2024年第9期1989-1991,共3页World Journal of Sleep Medicine

摘　　要：目的:观察替勃龙与芬吗通改善围绝经期患者睡眠情况。方法:选取2023年1月至2023年8月南平市浦城妇幼保健院收治的围绝经期综合征患者68例作为研究对象,按照随机数字表法随机分为对照组和观察组,每组34例。对照组口服替勃龙、观察组口服复方雌二醇片,疗程3个月。比较2组治疗前后匹兹堡睡眠质量量表(PSQI)评分、雌激素水平[黄体生成素(LH)、促卵泡激素(FSH)、雌二醇(E_(2))]、临床症状[围绝经期生命质量量表(MENQOL)、改良Kupperman评分],并记录不良反应情况。结果:治疗后2组PSQI评分、LH、FSH、MENQOL评分、改良Kupperman评分下降,E_(2)水平与治疗前比较上升(均P<0.05),但对照组与观察组治疗后比较,差异均无统计学意义(均P>0.05);2组不良反应总发生率(5.88%vs 8.82%)比较,差异无统计学意义(P>0.05)。结论:替勃龙与芬吗通治疗围绝经期综合征患者临床疗效相当,对患者睡眠的改善作用也相似,且安全性均良好。Objective:To observe the Effects of Tibolone and Estradiol/dydrogesterone on Sleep in Perimenopausal Patients.Methods:A total of 68 patients with perimenopausal syndrome treated at Nanping Pucheng Maternal and Child Health Hospital from January 2023 to August 2023 were selected as the study subjects.They were randomly divided into a control group and an observation group,with 34 cases in each group,using a random number table method.The control group received oral tibolone,while the observation group received oral compound Estradiol/dydrogesterone tablets,with a treatment duration of three months.The Pittsburgh Sleep Quality Index(PSQI)scores,estrogen levels[luteinizing hormone(LH),follicle-stimulating hormone(FSH),estradiol(E_(2))],clinical symptoms[Menopausal Quality of Life Scale(MENQOL),modified Kupperman scoring],and adverse reactions were compared before and after treatment.Results:After treatment,both groups showed a decrease in PSQI scores,LH,FSH,and MENQOL scores,as well as a rise in E_(2)levels compared to before treatment(all P<0.05).However,there was no statistically significant difference between the control and observation groups after treatment(all P>0.05).The total incidence of adverse reactions between the two groups(5.88%vs.8.82%)was also not statistically significant(P>0.05).Conclusion:Tibolone and Estradiol/dydrogesterone have comparable clinical efficacy in treating perimenopausal syndrome patients,with similar effects on improving sleep,and both treatments demonstrate good safety profiles.

关 键 词：替勃龙 雌二醇 雌二醇芬吗通 围绝经期 睡眠障碍 睡眠质量表 疗效 观察 

分 类 号：R338.63[医药卫生—人体生理学]