心脉隆注射液对慢性心力衰竭并阻塞性睡眠呼吸暂停低通气综合征患者疗效研究  

Efficacy of Xinmailong Injection in Patients with Chronic Heart Failure and Obstructive Sleep Apnea-hypopnea Syndrome

作　　者：欧志彬 OU Zhibin(Department of Cardiology,Hui′an County Hospital,Hui′an 362100,China)

机构地区：[1]惠安县医院心内科,惠安362100

出　　处：《世界睡眠医学杂志》2024年第9期2122-2124,共3页World Journal of Sleep Medicine

摘　　要：目的:观察心脉隆注射液辅助治疗改善慢性心力衰竭(CHF)并阻塞性睡眠呼吸暂停低通气综合征(OSAHS)患者通气功能及睡眠质量的效果。方法:选取2020年11月至2023年11月惠安县医院心内科收治的CHF并OSAHS患者68例作为研究对象,按照随机数字表法随机分为观察组和对照组,每组34例。对照组予以常规基础治疗,观察组联合心脉隆注射液。比较2组治疗前、治疗2周后通气功能、主观睡眠质量、心功能及不良反应。结果:治疗后,2组AHI、最长低通气时间、PSQI各维度评分及NT-proBNP均较治疗前下降,且观察组低于对照组(P<0.05),L-SpO_(2)、LVEF均较治疗前提高,观察组高于对照组(P<0.05);治疗期间,观察组、对照组分别有2例、1例患者用药后出现恶心症状,分别有3例、2例出现头晕症状,症状均较为轻微,可自行缓解,2组不良反应总发生率比较,差异无统计学意义(P>0.05)。结论:心脉隆注射液辅助治疗可显著改善CHF并OSAHS患者的通气功能、睡眠质量及心功能,且具有良好的安全性。Objective:To observe the effect of Xinmailong injection as an adjunctive treatment on improving ventilation function and sleep quality in patients with chronic heart failure(CHF)and obstructive sleep apnea-hypopnea syndrome(OSAHS).Methods:A total of 68 patients with CHF and OSAHS,admitted to Hui′an County Hospital from November 2020 to November 2023,were randomly divided into an observation group and a control group,with 34 patients in each group.The control group received routine treatment,while the observation group was treated with Xinmailong injection in addition to routine care.The ventilation function,subjective sleep quality,cardiac function,and adverse reactions were compared between the two groups before and after 2 weeks of treatment.Results:After treatment,both groups showed a reduction in apnea-hypopnea index(AHI),longest hypopnea time,Pittsburgh Sleep Quality Index(PSQI)scores,and NT-proBNP levels compared to pre-treatment values,with the observation group showing more significant improvements(P<0.05).Additionally,the lowest oxygen saturation(L-SpO_(2))and left ventricular ejection fraction(LVEF)increased in both groups,with greater improvements seen in the observation group(P<0.05).During the treatment,2 patients in the observation group and 1 patient in the control group reported mild nausea,and 3 patients in the observation group and 2 in the control group experienced dizziness;these symptoms were mild and resolved on their own.There was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusion:Xinmailong injection as an adjunctive treatment can significantly improve ventilation function,sleep quality,and cardiac function in patients with CHF and OSAHS,with good safety.

关 键 词：心脉隆注射液 慢性心力衰竭 阻塞性睡眠呼吸暂停低通气综合征 通气功能 睡眠质量 

分 类 号：R541.6[医药卫生—心血管疾病] R338.63[医药卫生—内科学]