无水乙腈含水量对^(18)F-FDG标记率的影响及控制  

The Effect and Control of Moisture Content of Anhydrous Acetonitrile on Synthesis Efficiency of^(18)F-FDG

作　　者：尹长峰 金光明 李钰 仝学峰 高慧媛[1] Yin Changfeng;Jin Guangming;Li Yu;Tong Xuefeng;Gao Huiyuan(College of Chinese Medicine,Shenyang Pharmaceutical University,Liaoning,110016;Atomic Hi-Tech Co.,Ltd.,Beijing,102413;Shenzhen CNNC Haidewei Biotechnology Co.,Ltd.,Guangdong,518005)

机构地区：[1]沈阳药科大学中药学院,辽宁110016 [2]原子高科股份有限公司,北京102413 [3]深圳市中核海得威生物科技有限公司,广东518005

出　　处：《当代化工研究》2024年第21期59-61,共3页Modern Chemical Research

摘　　要：目的:降低无水乙腈中含水量对^(18)F-FDG标记率的影响,建立无水乙腈含水量的控制质量标准。方法:通过优化无水乙腈分装的生产过程,降低无水乙腈分装和储存过程中水分的引入。结果:无水乙腈含水量高低会对^(18)F-FDG标记率产生影响。结论:自制分装的无水乙腈不影响^(18)F-FDG标记率,可以用于^(18)F-FDG的生产合成。Objective:To reduce the effect of water content in anhydrous acetonitrile on the labeling rate of^(18)F-FDG,and to establish a quality standard for controlling the water content of anhydrous acetonitrile.Methods:By optimizing the production process of anhydrous acetonitrile dispensing,the introduction of water during the process of anhydrous acetonitrile dispensing and storage was reduced.Results:The moisture content of anhydrous acetonitrile will affect the^(18)F-FDG labeling rate.Conclusion:The anhydrous acetonitrile in homemade dispensing does not affect the^(18)F-FDG labeling rate and can be used for the production and synthesis of^(18)F-FDG.

关 键 词：无水乙腈含水量 ^(18)F-FDG 标记率 

分 类 号：O642[理学—物理化学]