低分子量肝素盐的精制工艺及其临床应用研究进展  

Research Progress in Preparation and Clinical Application of Low Molecular Weight Heparin Salt

作　　者：蔡鑫鑫 袁建梅[1] 李曰珍 谭新强 李志利 邵敬增 汪应灵[1] CAI Xinxin;YUAN Jianmei;LI Yuezhen;TAN Xinqiang;LI Zhili;SHAO Jingzeng;WANG Yingling(School of Basic Medical Sciences,Xinxiang Medical University,Xinxiang Henan 453003,China;Henan Tuoren Medical Technology Co.,Ltd.,Xinxiang Henan 453000,China)

机构地区：[1]新乡医学院基础医学院,河南新乡453003 [2]河南省驼人医疗科技有限公司,河南新乡453000

出　　处：《当代化工》2024年第11期2720-2724,2730,共6页Contemporary Chemical Industry

基　　金：国家自然科学基金项目(项目编号:22276159);河南省科技攻关项目(项目编号:232102310407);驼人产学研合作项目(项目编号:2022410717000005);新乡医学院博士届满考核优秀资助项目(项目编号:XYBSKYZZ201514);新乡医学院研究生科研创新支持计划项目(项目编号:YJSCX202260Y)。

摘　　要：低分子量肝素盐(LMWHs)具有吸收效果好、生物利用率高等优点,被广泛应用于防治血栓栓塞性疾病。目前,有关LMWHs制备研究进展的综述比较少,有必要进一步系统总结新开发的LMWHs生物活性和药理作用。通过深入调研LMWHs的最新研究成果和实践应用,简单介绍了肝素产品的发展历程,梳理了LMWHs常用的制备方法及其优缺点,重点阐述了新近报道的化学解聚法的研究结果,探讨了LMWHs在血液分析、心血管疾病、肺病、肾病、癌症及治疗新型冠状病毒感染等方面的临床用途,为LMWHs的工业生产、应用开发策略提供有价值的参考信息。Low molecular weight heparin salts(LMWHs)are widely used in the prevention and treatment of thromboembolic diseases due to their good absorption effect and high bioavailability.At present,there are few reviews on the preparation progress of LMWHs.It is necessary to further systematically summarize the newly developed biological activities and pharmacological effects.On the basis of in-depth investigation of the latest research results and application practice of LMWHs,the development history of heparin products was briefly introduced,the commonly used preparation methods of LMWHs and their advantages and disadvantages were reviewed,and the recently reported research results of chemical depolymerization method were emphasized.The clinical application of LMWHs in blood analysis,cardiovascular disease,lung disease,kidney disease,cancer and treatment of COVID-19 was discussed,providing valuable reference information for industrial production,application-development of LMWHs.

关 键 词：低分子量肝素 肝素盐 制备方法 临床应用 

分 类 号：TQ064[化学工程] R973[医药卫生—药品]