山柰酚抗乳腺癌作用机制研究进展  

Mechanism of Kaempferol Against Breast Cancer and Its Research Progress

作　　者：佟茜 江晨 马会园 张莹[1,2] TONG Qian;JIANG Chen;MA Huiyuan;ZHANG Ying(First Teaching Hospital of Tianjin University of Traditional Chinese Medicine,Tianjin 300381,China;National Clinical Research Center for Chinese Medicine Acupuncture and Moxibustion,Tianjin 300381,China;Tianjin University of Traditional Chinese Medicine,Tianjin 301617,China)

机构地区：[1]天津中医药大学第一附属医院,天津300381 [2]国家中医针灸临床医学研究中心,天津300381 [3]天津中医药大学,天津301617

出　　处：《辽宁中医药大学学报》2024年第12期67-71,共5页Journal of Liaoning University of Traditional Chinese Medicine

基　　金：国家自然科学基金(82104553)。

摘　　要：国际癌症研究机构(IARC)统计显示,2020年全球乳腺癌新增病例超过230万例,已超过肺癌成为全球最常见的癌症,严重危害人类健康。山柰酚存在于许多蔬菜水果及中草药中,具有广泛的药理活性,包括抗肿瘤、抗炎、抗氧化、改善脑缺血、降糖、抗骨质疏松、抗菌、保护损伤组织、抗焦虑活性。越来越多的研究表明,山柰酚在抗乳腺癌方面表现出了巨大潜力,主要通过诱导乳腺癌细胞凋亡以及抑制乳腺癌细胞增殖、代谢及迁袭转移等途径来发挥抗乳腺癌作用。此外,还有研究表明山柰酚可通过逆转乳腺癌细胞耐药性来增强抗乳腺癌药物细胞毒性。山柰酚可通过多种途径来发挥抗乳腺癌作用,在临床抗乳腺癌治疗中具有广泛的应用前景。文章对近几年山柰酚抗乳腺癌作用机制的研究进展进行综述,以期为研究开发山柰酚的抗乳腺癌作用和临床应用提供理论基础。According to the statistics of the International Agency for Research on Cancer(IARC),there are more than 2.3 million new cases of breast cancer in the world in 2020,which has surpassed lung cancer to become the most common cancer in the world,seriously endangering human health.Kaempferol exists in many vegetables,fruits and Chinese herbal medicine,and has a wide range of pharmacological activities,including anti-tumor,anti-inflammatory,anti-oxidation,improving cerebral ischemia,reducing blood sugar,anti-osteoporosis,antibacterial,protecting injured tissue,anti-anxiety activity.More and more studies have shown that Kaempferol shows great potential in anti-breast cancer,mainly by inducing breast cancer cell apoptosis and inhibiting breast cancer cell proliferation,metabolism and metastasis.In addition,studies have shown that Kaempferol can enhance the cytotoxicity of anti-breast cancer drugs by reversing the drug resistance of breast cancer cells.Kaempferol can exert its anti-breast cancer effect in many ways and has a wide application prospect in clinical anti-breast cancer therapy.This paper reviews the research progress on the anti-breast cancer mechanism of Kaempferol in recent years,in order to provide a theoretical basis for the research and development of the anti-breast cancer effect and clinical application of Kaempferol.

关 键 词：山柰酚 乳腺癌 细胞增殖 细胞凋亡 作用机制 

分 类 号：R285[医药卫生—中药学]