鸦胆子抗肿瘤活性成分及其作用机制研究进展  

Progress in the Study of Anti-tumor Active Components of Yadanzi(Bruceae Fructus)and Its Mechanism of Action

作　　者：彭本钊 严首春 PENG Benzhao;YAN Shouchun(Shaanxi University of Chinese Medicine,Xianyang 712000,Shaanxi,China;The Second Affiliated Hospital of Shaanxi University of Chinese Medicine,Xianyang 712000,Shaanxi,China)

机构地区：[1]陕西中医药大学,陕西咸阳712000 [2]陕西中医药大学第二附属医院,陕西咸阳712000

出　　处：《辽宁中医药大学学报》2024年第12期213-220,共8页Journal of Liaoning University of Traditional Chinese Medicine

基　　金：陕西中医药大学校级项目(303-17102032046)。

摘　　要：鸦胆子具有清热解毒、截疟、凉血止痢、杀虫、抗肿瘤,外用消痔、腐蚀赘疣的功效,其化学成分复杂,药理作用丰富。现代药理学研究发现鸦胆子中含有多种生物活性成分,包括苦木内酯类、苯丙素类、黄酮类、三萜类、甾体类、生物碱类、黄花菜木酯素、脂肪酸类和酚酸类等,可通过多种途径显著抑制肿瘤黏附、增殖、转移、侵袭,诱导肿瘤细胞分化和凋亡、抑制肿瘤组织血管的生成、阻滞细胞周期,显著抑制肿瘤进展。鸦胆子对多种恶性肿瘤具有显著抑制作用,包括结直肠癌、肝癌、肺癌、卵巢癌、乳腺癌、胰腺癌、食管癌、膀胱癌、白血病、骨肉瘤及肾细胞癌等。通过对鸦胆子的抗肿瘤活性成分和作用机制进行分析综合,为鸦胆子抗肿瘤的深入研究和新药开发提供理论依据。Yadanzi(Bruceae Fructus)has the efficacy of clearing heat and detoxification,intercepting malaria,cooling blood and stopping diarrhoea,killing insects,anti-tumour,eliminating haemorrhoids externally and corroding warts,and the efficacy of its chemical composition is complex and rich in pharmacological effects.Modern pharmacological studies have found that Yadanzi(Bruceae Fructus)contains a variety of bioactive components,including bitter wood lactones,phenylpropanoids,flavonoids,triterpenoids,steroids,alkaloids,xanthophyll lignans,fatty acids,and phenolic acids,which can significantly inhibit tumor adhesion,proliferation,metastasis,and invasion through a variety of pathways,induce tumor cell differentiation and apoptosis,and inhibit angiogenesis in tumor tissues,block the cell cycle,and significantly inhibit tumor progression.Yadanzi(Bruceae Fructus)has a significant inhibitory effect on a variety of malignant tumours,including:colorectal cancer,hepatocellular carcinoma,lung cancer,ovarian cancer,breast cancer,pancreatic cancer,oesophageal cancer,bladder cancer,leukaemia,osteosarcoma,and renal cell carcinoma.By analysing and synthesizing the anti-tumor active components and mechanism of action of Yadanzi(Bruceae Fructus),we can provide a theoretical basis for the in-depth study of Yadanzi(Bruceae Fructus)anti-tumor and the development of new drugs.

关 键 词：鸦胆子 抗肿瘤 研究进展 作用机制 活性成分 

分 类 号：R282.71[医药卫生—中药学]