国内关于化疗药物心脏毒性的研究现状——基于CiteSpace软件的可视化分析  

Current Research Status on Cardiovascular Toxicity of Chemotherapy Drugs in China——Visual Analysis Based on CiteSpace Software

作　　者：贾佳慧 张娟[2] 王玉修 张启程 魏希进[2] JIA Jiahui;ZHANG Juan;WANG Yuxiu;ZHANG Qicheng;WEI Xijin(Shandong University of Traditional Chinese Medicine,Jinan,Shandong 250014;Affiliated Hospital of Shandong University of Traditional Chinese Medicine,Jinan,Shandong 250014)

机构地区：[1]山东中医药大学,山东济南250014 [2]山东中医药大学附属医院,山东济南250014

出　　处：《内蒙古中医药》2024年第11期158-163,共6页Inner Mongolia Journal of Traditional Chinese Medicine

基　　金：山东省中医药科技发展计划项目(2021M180);山东省自然科学基金联合基金重点支持项目(ZR2021LZY038);齐鲁流派中医学术流派传承项目(鲁卫函[2022]93号)。

摘　　要：目的:基于CiteSpace软件,可视化分析近10年国内关于化疗药物心脏毒性领域的研究热点,研究现状和发展趋势。方法:以中国知网数据库为数据源,检索2013年1月-2023年4月收录的化疗药物心脏毒性相关文献,借助CiteSpace软件,分别对纳入文献的作者,机构,关键词等方面进行可视化图谱分析。结果:经筛选最终纳入中文文献557篇,通过对文献的可视化分析可知:该领域年发文量趋势较为稳定;发文量最多的作者是俸艳英;发表文献较多的研究机构是天津中医药大学、北京中医药大学中医学院;关键词图谱形成312个节点,1009条连线,18个聚类,“阿霉素”、“乳腺癌”和“右丙亚胺”是出现频率最高的3个关键词。涉及范围较广的前2个关键词聚类标签为#乳腺癌,#阿霉素。近5年出现频次较高的关键词是“氧化应激”。结论:国内关于化疗药物心脏毒性的研究整体呈波动上升趋势。各机构、作者应加强交流合作,促进合作网络形成。该领域研究内容主要集中于乳腺癌,阿霉素和右丙亚胺等方面。在未来,开展大量细胞实验和动物实验,明确化疗药物心脏毒性的发生机制,构建风险预测模型,增加临床研究,探索多元化治疗方案等或将成为研究热点。Objective:Based on CiteSpace software,visually analyze the domestic research hotspots,research status and development trends in the field of chemotherapeutic drug cardiotoxicity in the past 10 years.Methods:Using the China Knowledge Network database as the data source,the literatures related to cardiotoxicity of chemotherapeutic drugs collected from January 2013 to April 2023 were searched.With the help of CiteSpace software,visual atlas analysis was carried out on the authors,institutions,keywords and other aspects of the included literatures.Results:After screening,557 Chinese literatures were finally included.Through visual analysis of the literatures,it can be seen that the annual trend of publication volume in this field is relatively stable;the author with the largest number of publications is Feng Yanying;the research institutions with more publications are Tianjin University of Traditional Chinese Medicine and School of Traditional Chinese Medicine,Beijing University of Chinese Medicine;The keyword atlas has 312 nodes,1009 links,and 18 clusters."Adriamycin",breast cancer"and"dexalimine"are the three keywords with the highest frequency of occurrence.The top two keyword clusters with a wide range of topics are#breast cancer and#doxorubicin.The keyword that has appeared frequently in the past five years is"oxidative stress".Conclusion:Domestic research on cardiotoxicity of chemotherapeutic drugs shows an overall fluctuating and increasing trend.All institutions and authors should strengthen exchanges and cooperation and promote the formation of cooperation networks.The research content in this field mainly focuses on breast cancer,doxorubicin and dexalimine.In the future,conducting a large number of cell experiments and animal experiments,clarifying the mechanism of cardiotoxicity of chemotherapeutic drugs,building risk prediction models,increasing clinical research,and exploring diversified treatment options may become research hotspots.

关 键 词：化疗药物 心脏毒性 CITESPACE 可视化分析 

分 类 号：R979.1[医药卫生—药品]