高海拔地区先天性心脏病低氧环境和遗传因素的研究进展  

Research progress on hypoxia environment and genetic factors for congenital heart dis-ease at high altitudes

作　　者：秦珊珊 高寒 旦增顿珠[1] 张宇鹏 Qin Shanshan;GaoHan;Danzeng Dunzhu;Zhang Yupeng(Xizang University School of Medicine,Xizang 850000;Qilu Medical College School of Stomatology,Shandong Zibo 255000)

机构地区：[1]西藏大学医学院,西藏拉萨850000 [2]齐鲁医药学院口腔医学院,山东淄博255000

出　　处：《西藏医药》2024年第6期139-140,共2页Tibetan Medicine

摘　　要：先天性心脏病是婴幼儿出生缺陷中最常见的疾病之一,严重威胁婴幼儿生命和健康,给社会和家庭带来沉重负担。高海拔地区先天性心脏病患病率远高于平原地区,大量研究证明高海拔地区低氧是导致先天性心脏病主要因素。因此,明确高海拔地区低氧环境与先天性心脏病相关机制,可以有效预防和降低先天性心脏病的发病率。本综述总结了高海拔地区先天性心脏病的发病机制中遗传和环境因素。Congenital heart disease is one of the most common diseases among infant birth defects,which seriously threatens the lives and health of infants and puts a heavy burden on society and families.The prevalence of congenital heart disease in high-altitude areas is much higher than that in plain areas.A large number of studies have proved that hypoxia in high-altitude areas is the main factor leading to congenital heart disease.Therefore,clarifying the mechanism related to hypoxic environment and congenital heart disease in high-altitude areas can effectively prevent and reduce the incidence of congenital heart disease.This review summarizes genetic and environmental factors in the pathogenesis of congenital heart disease at high altitudes.

关 键 词：先天性心脏病 低氧 高海拔地区 

分 类 号：R725.4[医药卫生—儿科]