浅析三带型基因座同一认定似然比的计算策略  

A Preliminary Analysis of the Calculation Strategy for the Likelihood Ratio of Identity Identification of Tri-allelic Pattern Loci

作　　者：海璇隽 黄建春[2] HAI Xuanjun;HUANG Jianchun(Criminal Investigation Detachment,Longyan Public Security Bureau,Longyan 364000,China;Criminal Technology Corps,Fujian Provincial Public Security Department,Fuzhou 350001,China)

机构地区：[1]龙岩市公安局刑事侦查支队,福建龙岩364000 [2]福建省公安厅刑事技术总队,福建福州350001

出　　处：《中国司法鉴定》2024年第5期68-71,共4页Chinese Journal of Forensic Sciences

摘　　要：目的探讨短串联重复序列(short tandem repeat,STR)三带型基因座同一认定似然比(likelihood ratio,LR)的不同计算策略。方法通过忽略三带型基因座、基于人群中不同类型的观测值、基于三带型基因座形成机制推导公式三个模型,对三带型基因座似然比进行计算。结果得到三个模型六种策略的LR计算方法,并分析其保守性与局限性。结论根据三体综合征发生机制推导的三带型基因座LR计算公式,可得到较为准确且可用于司法鉴定的LR值。Objective To explore different calculation strategies for the likelihood ratio(LR)identity identification of tri-allelic pattern short tandem repeat(STR)loci.Methods Calculated the LR of tri-allelic pattern loci by ignoring the tri-allelic pattern loci,based on observations values in population,and based on the formula derivated from the mechanism of tri-allelic pattern loci.Results The LR calculation methods for three models and six strategies were obtained,and their conservatism and limitations were analyzed.Conclusion The LR calculation formula for tri-allelic pattern loci can be derived based on the mechanism of trisomy syndrome,enabling the acquisition of more accurate LR values applicable in forensic appraisal.

关 键 词：法医遗传学 短串联重复序列 三带型 似然比 

分 类 号：DF795.2[医药卫生—法医学]