中医药领域代谢组学整合网络药理学研究概况  

Overview of metabonomics integrated network pharmacology in the field of TCM

作　　者：黄显清 赵博 杨扬[1] Huang Xianqing;Zhao Bo;Yang Yang(College of Pharmacy,Guilin Medical University,Guilin 541000,China)

机构地区：[1]桂林医学院药学院,桂林541000

出　　处：《国际中医中药杂志》2024年第11期1526-1530,共5页International Journal of Traditional Chinese Medicine

基　　金：国家自然科学基金(32060090);广西自然科学基金(2021JJA130119);广西药物分子发现与成药性优化重点实验室开放课题(GKLPMDDO-2022-C02)。

摘　　要：代谢组学技术以生物体内小分子代谢物为研究对象,通过现代技术从整体上解析生物体内的动态代谢变化,多维度阐释其病理生理体系。而网络药理学则从系统上探索药物与疾病的相关性。将网络药理学与代谢组学相结合开展研究,符合中医药系统性和整体性的思维模式。目前,二者的整合技术在中药单药、药对、复方药效物质基础和机制、中药毒性机制、中药质量及成分、中药炮制机制等研究中均有一定应用,可实现从差异代谢物挖掘中药复杂体系有效成分,进而寻找中药核心作用基因和靶标蛋白,揭示中药防治疾病的生物途径,具有快速、有效辨识中药药效和物质基础和阐明其作用机制的优势。但二者联用时缺乏对外源性成分及其相关靶点的获取,易存在假阳性结果,整体水平单一且局限性大,故需进一步思考并加以完善。Metabonomics technology takes small molecular metabolites in organisms as the research object,analyzes the dynamic metabolic changes in organisms as a whole through modern technology,and explains its pathophysiological system in multiple dimensions.Network pharmacology is to systematically explore the correlation between drugs and diseases.The combination of network pharmacology and metabolomics is in line with the systematic and holistic thinking mode of TCM.At present,the integration technology of the two has certain applications in the research of TCM single drug,medicinal pair,material basis and mechanism of compound efficacy,toxic mechanism of Chinese materia medica,quality and composition of Chinese materia medica,and processing mechanism of Chinese materia medica.It can realize the effective components of the complex system of Chinese materia medica from the differential metabolites,and then find the core genes and target proteins of Chinese materia medica,and reveal the biological pathway of Chinese materia medica to prevent and treat diseases.It has the advantages of quickly and effectively identifying the efficacy and material basis of Chinese materia medica and clarifying its mechanism.However,the combination of the two lacks the acquisition of exogenous components and their related targets,and is prone to false positive results.The overall level is single and limited,so it needs to be further considered and improved.

关 键 词：中医药学 代谢组学 网络药理学 应用概况 综述 

分 类 号：R285[医药卫生—中药学]