纳米中药对支气管哮喘的调控作用  

The regulation of nano-traditional Chinese medicine in bronchial asthma

作　　者：杨正富 段凌志 王燕 张爱华 胡金 张俊图 景海卿 左成扩 付义 魏丹霞 YANG Zhengfu;DUAN Lingzhi;WANG Yan;ZHANG Aihua;HU Jin;ZHANG Juntu;JING Haiqing;ZUO Chengkuo;FU Yi;WEI Danxia(Yunnan University of Traditional Chinese Medicine,Kunming 650500,China;Department of Pulmonary Diseasem,The Third Affiliated Hospital of Yunnan University of Traditional Chinese Medicine,Kunming 650500,China;College of Fundamental and Pharmacy,Yunnan College of Medicine and Health,Kunming 650033,China;Department of Internal Medicine,Dongchuan Hospital of Traditional Chinese Medicine,Kunming 654100,China;Department of Nephrology,The Third Affiliated Hospital of Yunnan University of Traditional Chinese Medicine,Kunming 650500,China)

机构地区：[1]云南中医药大学,昆明650500 [2]云南中医药大学第三附属医院肺病科,昆明650500 [3]云南医药健康职业学院基础与药学院,昆明650033 [4]东川区中医医院内科,昆明654100 [5]云南中医药大学第三附属医院肾病科,昆明650500

出　　处：《生命的化学》2024年第11期2108-2118,共11页Chemistry of Life

基　　金：国家自然科学基金项目(82260921);云南省科技厅科技计划项目(202101AZ070001-100);昆明市卫生健康委员会科研课题项目(2022-03-06-020)。

摘　　要：支气管哮喘(简称哮喘)的发病率逐年升高,对社会及患者的家庭经济造成严重负担,但也促进了哮喘相关领域研究的发展。以中西医结合思想为指导的纳米中药开发与研究是哮喘防治中的热点问题之一。研究显示,纳米中药可有效减轻哮喘的气道炎症及氧化应激反应,并降低气道高反应性,实现体内控释及靶向治疗作用,可能成为治疗或控制哮喘发作的潜在手段。因此,本文阐述了调控哮喘的纳米中药开发现状及其干预哮喘的作用机制,旨在为中医药防治哮喘及新药开发提供思路和依据。The incidence of bronchial asthma(asthma for short)has been increasing year by year,which has caused a serious burden on the society and the family economy of the patients,but has also promoted the development of asthma-related research fields.The development and research of nano-herbal medicine guided by the idea of integrating Chinese and Western medicine is one of the hot issues in asthma prevention and treatment.Studies have shown that nanoherbal medicines can effectively reduce airway inflammation and oxidative stress in asthma and decrease airway hyperresponsiveness,which can realize in vivo controlled release and targeted therapeutic effects,or potential means for the treatment or control of asthma attacks.Therefore,the aim of this paper is to describe the current status of the development of nano-Chinese medicines for the regulation of asthma and their mechanism of action in interfering with asthma,which is intended to provide a basis for the idea of Chinese medicine for the prevention and treatment of asthma and the development of new drugs.

关 键 词：支气管哮喘 中药分子 分子配伍 纳米技术 中药药理学 

分 类 号：R256.12[医药卫生—中医内科学]