再程放疗与热疗联合治疗复发性乳腺癌研究进展  

Research progress in the treatment of recurrent breast cancer with re-irradiation and hyperthermia

作　　者：常添添 段伟[1] CHANG Tiantian;DUAN Wei(Yan’an University Affiliated Hospital,Yan’an 716000 China)

机构地区：[1]延安大学附属医院,陕西延安716000

出　　处：《中国辐射卫生》2024年第5期615-620,共6页Chinese Journal of Radiological Health

摘　　要：乳腺癌是全球女性的主要癌症之一,尽管5年生存率很高,却也是癌症相关死亡的最常见原因之一。手术、全身治疗和放射治疗是乳腺癌根治性治疗的三大支柱。而经历过首次放疗的乳腺癌患者,仍然有不少在先前治疗过的区域复发或发展为继发性癌症的人。这些患者需要再次治疗,而再程照射与热疗则是复发性乳腺癌不可忽视的治疗方法。放射治疗也可以与局部热疗相结合,使肿瘤细胞对辐射敏感,从而降低所需的辐射剂量。轻度局部高热和减少总剂量的再程照射的联合治疗是先前接受过照射的乳腺癌患者的相关治疗选择。再程放疗与热疗联合治疗也是目前肿瘤综合治疗的热点之一。本文从再程放疗和热疗的定义、类型,各类复发性乳腺癌的常见放疗方式,单一放疗或热疗治疗复发性乳腺癌及热疗联合放疗对肿瘤细胞免疫表型的影响和机制等多方面概述和归纳再程放疗与热疗联合时治疗复发性乳腺癌的序列及热疗最佳温度的研究进展,为再程放疗联合热疗治疗复发性乳腺癌的最佳疗效评估提供科学基础。Breast cancer is one of the major cancers affecting women globally.Although the five-year survival rate is very high,it is one of the most common causes of cancer-related deaths.Surgery,systemic therapy,and radiotherapy are the three pillars of radical treatment of breast cancer.However,for breast cancer patients who have undergone initial radiotherapy,many experience relapse or develop secondary cancers in the previously treated areas.These patients need to be treated again,and re-irradiation and hyperthermia are important treatment methods for recurrent breast cancer.Radiotherapy can be combined with local hyperthermia to make tumor cells sensitive to radiation,thereby reducing the required radiation dose.The combination of mild local hyperthermia and re-irradiation with reduced total dose is a treatment option for breast cancer patients who have previously received radiation.The combination of re-irradiation and hyperthermia is currently a hotspot of comprehensive tumor treatment.This article summarizes the research progress on the sequence of recurrent breast cancer and the optimal temperature of hyperthermia in treatment with re-irradiation and hyperthermia.Specifically,this article reviews the definition and type of re-irradiation and hyperthermia,the common radiotherapy methods for various types of recurrent breast cancer,and the effect of radiotherapy,hyperthermia,or their combination on the immune phenotype of tumor cells and its mechanism.Our results provide a scientific basis for the evaluation of the optimal efficacy of re-irradiation combined with hyperthermia in treating recurrent breast cancer.

关 键 词：复发性乳腺癌 再程放疗 放疗技术 热疗 

分 类 号：R815[医药卫生—放射医学]