高通量与低通量透析对维持性血液透析患者炎症因子水平的影响  

Effects of high-flux and low-flux dialysis on inflammatory factors levels in maintenance hemodialysis patients

作　　者：张刚兴 兰琳 黄伟军 ZHANG Gangxing;LAN Lin;HUANG Weijun(Gem Flower Xi'an Changqing Staff Hospital,Xi'an 710201;Xi'an Eighth Hospital,Xi'an 710061,China)

机构地区：[1]西安宝石花长庆医院,陕西西安710201 [2]西安市第八医院,陕西西安710061

出　　处：《临床医学研究与实践》2024年第33期87-90,共4页Clinical Research and Practice

摘　　要：目的分析高通量与低通量透析对维持性血液透析患者炎症因子水平的影响。方法选取2022年1月至2023年1月收治的200例维持性血液透析患者作为研究对象,根据随机数字表法将其分为对照组(n=100)和观察组(n=100)。对照组采用低通量透析治疗,观察组采用高通量透析治疗。比较两组的治疗效果。结果治疗后,观察组的胱抑素C(CysC)、尿素氮(BUN)及血肌酐(Scr)水平低于对照组(P<0.05)。治疗后,观察组的肿瘤坏死因子-α(TNF-α)、超敏C反应蛋白(hs-CRP)及白细胞介素-6(IL-6)水平低于对照组(P<0.05)。治疗后,观察组的超氧化物歧化酶(SOD)水平高于对照组,丙二醛(MDA)水平低于对照组(P<0.05)。治疗后,观察组的白蛋白(ALB)、总蛋白(TP)水平高于对照组(P<0.05)。观察组的并发症总发生率为3.00%,低于对照组的11.00%(P<0.05)。结论高通量透析对维持性血液透析患者的应用效果显著,能改善肾功能和营养状态,调节炎症因子和氧化应激指标,降低并发症的发生风险。Objective To analyze the effects of high-flux and low-flux dialysis on inflammatory factors levels in maintenance hemodialysis patients.Methods A total of 200 patients with maintenance hemodialysis admitted from January 2022 to January 2023 were selected as the research objects and divided into control group(n=100)and observation group(n=100)by random number table method.The control group was treated with low-flux dialysis,and the observation group was treated with high-flux dialysis.The therapeutic effects of the two groups were compared.Results After treatment,the levels of cystatin C(CysC),blood urea nitrogen(BUN)and serum creatinine(Scr)in the observation group were lower than those in the control group(P<0.05).After treatment,the levels of tumor necrosis factor-α(TNF-α),hypersensitive C-reactive protein(hs-CRP)and interleukin-6(IL-6)in the observation group were lower than those in the control group(P<0.05).After treatment,the level of superoxide dismutase(SOD)in the observation group was higher than that in the control group,and the level of malondialdehyde(MDA)was lower than that in the control group(P<0.05).After treatment,the levels of albumin(ALB)and total protein(TP)in the observation group were higher than those in the control group(P<0.05).The total incidence of complications in the observation group was 3.00%,which was lower than 11.00%in the control group(P<0.05).Conclusion The high-flux dialysis has a significant effect on maintenance hemodialysis patients,which can improve renal function and nutritional status,regulate inflammatory factors and oxidative stress indicators,and reduce the risk of complications.

关 键 词：高通量透析 低通量透析 维持性血液透析 炎症因子 氧化应激 

分 类 号：R692.5[医药卫生—泌尿科学]