腹腔镜手术复位治疗小儿肠套叠的效果及对T淋巴细胞水平的影响  

Effect of laparoscopic surgical reduction in the treatment of pediatric intussusception and its influence on T lymphocyte level

作　　者：谭诗坤 TAN Shikun(Pediatric General Surgery Department,the First People's Hospital of Shangqiu City,Henan 476100,China)

机构地区：[1]商丘市第一人民医院小儿普外科,河南商丘476100

出　　处：《临床医学研究与实践》2024年第33期123-126,共4页Clinical Research and Practice

摘　　要：目的分析腹腔镜手术复位治疗小儿肠套叠的效果及对T淋巴细胞水平的影响。方法选取2020年9月至2023年9月我院收治的56例肠套叠患儿为研究对象,按照治疗方案的差异将其分为对照组和研究组,各28例。对照组接受开腹手术治疗,研究组接受腹腔镜手术复位治疗。比较两组的治疗效果。结果研究组的首次肛门排气时间、下床活动时间、恢复饮食时间、住院时间短于对照组,差异具有统计学意义(P<0.05);两组的复位成功率比较,差异无统计学意义(P>0.05)。术后24 h,两组的肿瘤坏死因子-α(TNF-α)、高迁移率组蛋白B1(HMGB1)、五聚素3(PTX3)、降钙素原(PCT)水平均升高,但研究组低于对照组,差异具有统计学意义(P<0.05)。术后24 h,研究组的CD3^(+)、CD4^(+)、CD4^(+)/CD8^(+)高于对照组,CD8^(+)低于对照组,差异具有统计学意义(P<0.05)。研究组的并发症总发生率低于对照组,差异具有统计学意义(P<0.05)。结论腹腔镜手术复位治疗小儿肠套叠的效果较好,术后炎性反应轻,对免疫指标影响小,可促进患儿术后恢复,具有较高的应用价值。Objective To analyze the effect of laparoscopic surgical reduction in the treatment of pediatric intussusception and its influence on T lymphocyte level.Methods A total of 56 children with intussusception admitted in our hospital from September 2020 to September 2023 were selected as the research objects.According to the difference of treatment plan,the children were divided into control group and study group,with 28 cases in each group.The control group received open surgery,and the study group received laparoscopic surgical reduction.The therapeutic effects of the two groups were compared.Results The first anal exhaust time,ambulation time,diet recovery time and hospitalization time of the study group were shorter than those of the control group,and the differences were statistically significant(P<0.05);there was no significant difference in the success rate of reduction between the two groups(P>0.05).At 24 h after operation,the levels of tumor necrosis factor-α(TNF-α),high mobility group protein B1(HMGB1),pentamerin 3(PTX3)and procalcitonin(PCT)in the two groups increased,but those in the study group were lower than the control group,and the differences were statistically significant(P<0.05).At 24 h after operation,the CD3^(+),CD4^(+)and CD4^(+)/CD8^(+)in the study group were higher than those in the control group,and the CD8^(+)was lower than that in the control group,the differences were statistically significant(P<0.05).The total incidence of complications in the study group was lower than that in the control group,the difference was statistically significant(P<0.05).Conclusion Laparoscopic surgical reduction is effective in the treatment of pediatric intussusception.The postoperative inflammatory response is mild,and the effect on immune index is small.The method can promote the postoperative recovery of children and has high application value.

关 键 词：小儿 肠套叠 腹腔镜手术复位 T淋巴细胞 

分 类 号：R726.5[医药卫生—儿科]