健脾消积方“苏打饼干”治疗非酒精性脂肪性肝病的临床效果  

Clinical effect of Jianpi Xiaoji prescription"soda biscuit"in the treatment of nonalcoholic fatty liver disease

作　　者：梅昭荷 郭玉卿 徐晓辉 赵辉 陈丽萍 聂红明 MEI Zhaohe;GUO Yuqing;XU Xiaohui;ZHAO Hui;CHEN Liping;NIE Hongming(Spleen and Stomach Disease Department,Integrated Traditional Chinese and Western Medicine Hospital of Minhang District,Shanghai 201100;Hepatology Department,Shanghai Traditional Chinese Medicine Hospital,Shanghai 200071,China)

机构地区：[1]上海市闵行区中西医结合医院脾胃病科,上海201100 [2]上海市中医医院肝病科,上海200071

出　　处：《临床医学研究与实践》2024年第33期171-174,共4页Clinical Research and Practice

摘　　要：目的探讨健脾消积方“苏打饼干”治疗非酒精性脂肪性肝病(NAFLD)的临床效果。方法选取2019年7月至2021年7月上海市闵行区中西医结合医院接诊的80例NAFLD患者,以随机数字表法将其分为对照组、观察组,各40例。对照组实施饮食控制及有氧运动锻炼,观察组在对照组基础上给予健脾消积方“苏打饼干”。比较两组的治疗效果,并分析疾病预后的影响因素。结果治疗后,观察组的体质指数(BMI)、腰臀比小于对照组(P<0.05);治疗后,观察组的γ-谷氨酰转肽酶(γ-GT)水平低于对照组(P<0.05);治疗后,两组的甘油三酯(TG)、总胆固醇(TC)及低密度脂蛋白(LDL)水平低于治疗前(P<0.05);观察组的影像学分级优于对照组(P<0.05);观察组的治疗总有效率高于对照组(P<0.05);两组均未发生不良事件。多元有序Logistic回归分析显示,年龄、病程是健脾消积方“苏打饼干”治疗NAFLD患者预后的影响因素(P<0.05)。结论健脾消积方“苏打饼干”治疗NAFLD患者的效果较好;年龄、病程是疾病预后的影响因素。Objective To investigate the clinical effect of Jianpi Xiaoji prescription"soda biscuit"in the treatment of nonalcoholic fatty liver disease(NAFLD).Methods A total of 80 patients with NAFLD who were admitted in the Integrated Traditional Chinese and Western Medicine Hospital of Minhang District from July 2019 to July 2021 were selected and divided into control group and observation group according to the random number table method,with 40 cases in each group.The control group was given diet control and aerobic exercise,and the observation group was given Jianpi Xiaoji prescription"soda biscuit"on the basis of the control group.The therapeutic effects of the two groups were compared,and the influencing factors of disease prognosis were analyzed.Results After treatment,the body mass index(BMI)and waist-to-hip ratio of the observation group were smaller than those of the control group(P<0.05);after treatment,the level ofγ-glutamyl transpeptidase(γ-GT)in the observation group was lower than that in the control group(P<0.05);after treatment,the levels of triglyceride(TG),total cholesterol(TC)and low density lipoprotein(LDL)in the two groups were lower than those before treatment(P<0.05);the imaging grading of the observation group was better than that of the control group(P<0.05);the total effective rate of treatment in the observation group was higher than that in the control group(P<0.05);no adverse events occurred in the two groups.Multivariate ordinal Logistic regression analysis showed that age and course of disease were the influencing factors of the prognosis of NAFLD patients treated with Jianpi Xiaoji prescription"soda biscuit"(P<0.05).Conclusion The Jianpi Xiaoji prescription"soda biscuit"in the treatment of NAFLD patients has better effect;age and course of disease are the influencing factors of disease prognosis.

关 键 词：非酒精性脂肪性肝病 药食同源 健脾消积方 预后 

分 类 号：R259[医药卫生—中西医结合]