Study on Antibacterial and Biocompatibility of Thermally Crosslinked Polyvinylpyrrolidone Nanofiber Iodine Complexes  

作　　者：XU Dejun HE Liu ZENG Fudong LIU Bo MA Jinli HAN Dongmei YANG Qingbiao DU Jianshi 

机构地区：[1]China-Japan Union Hospital of Jilin University,Changchun 130061,P.R.China [2]College of Chemistry,Jilin University,Changchun 130021,P.R.China [3]Key Laboratory of Lymphatic Surgery of Jilin Province,Engineering Laboratory of Lymphatic Surgery of Jilin Province,Changchun 130031,P.R.China

出　　处：《Chemical Research in Chinese Universities》2024年第6期1050-1059,共10页高等学校化学研究（英文版）

基　　金：supported by the Jilin Provincial Development and Reform Commission Industrial Technology Research and Development Project,China(No.2023C039-5);the Jilin Province Science and Technology Development Plan Project,China(No.20210204107YY);the Jilin Province Health Technology Capability Enhancement Project,China(No.2021LC028).

摘　　要：Polyvinylpyrrolidone-iodine (PVP-I) complexes are widely used in the medical and health field due to its strong antimicrobial properties and good biocompatibility,but their water solubility negates the possibility to be used as a wound dressing.In this work,the problem of PVP dissolving in water was solved by the method of thermally crosslinking,and it was found that the thermally crosslinked PVP nanofiber heated at 170 ℃ for 6 h had good liquid absorption capacity,stability and good fiber morphology.In addition,the thermally crosslinked PVP nanofiber is complexed with I2 to endow it with excellent antibacterial properties.It has been demonstrated to have good biocompatibility through cytotoxicity and hemolysis experiments,which provides the possibility for it to be a dressing for the treatment of infectious wounds.

关 键 词：Electrospinning Nanofiber membrane Thermally crosslinked polyvinylpyrrolidone ANTIMICROBIAL BIOCOMPATIBILITY 

分 类 号：O63[理学—高分子化学]