Reproductive Toxicities of Tetradecyltrimethylammonium Chloride and Tetradecyltrimethylammonium Bromide on Caenorhabditis elegans over Four Consecutive Generations  

作　　者：ZHANG Jing DING Ruoqi YU Zhenyang 

机构地区：[1]Ecological Technique and Engineering College,Shanghai Institute of Technology,Shanghai 201418,P.R.China [2]Jiaxing Tongji Institute for Environment,Jiaxing 314051,P.R.China [3]State Key Laboratory of Pollution Control and Resource Reuse,Key Laboratory of Yangtze River Water Environment,Ministry of Education,College of Environmental Science and Engineering,Tongji University,Shanghai 200092,P.R.China

出　　处：《Chemical Research in Chinese Universities》2024年第6期1060-1067,共8页高等学校化学研究（英文版）

基　　金：supported by the National Key Research and Development Program of China (No.2021YFC3200803);the National Natural Science Foundation of China (No.21976138).

摘　　要：Quaternary ammonium compounds (QACs) become emerging pollutants and their toxicities earn increasing attention.So far,their reproductive toxicities were poorly investigated,and their effects over generations were even less explored.In the present study,reproductive toxicities of two QACs,i.e.,tetradecyltrimethylammonium chloride (TTAC);tetradecyltrimethylammonium bromide (TTAB) were studied on Caenorhabditis elegans with a consecutive exposure over four generations (from F1 to F4).The effects of TTAC on total and initial reproduction showed stimulation and inhibition,which oscillated from F1 to F4.The effects of TTAB on the total reproduction commonly showed stimulation over generations with the greatest stimulation in F2,and it inhibited the initial reproduction but stimulated the reproduction duration.Further exploration demonstrated that TTAC and TTAB significantly disturbed the levels of spermatocyte protein 8 (SPE8);sperm transmembrane protein 9 (SPE9);vitellogenin (Vg);major sperm protein (MSP);ephrin receptor protein tyrosine kinase (VAB-1);the expressions of vab-1,ceh-18,set-2,met-2 and mes-4.Such disturbances demonstrated that both QACs impacted the reproductive processes via oocyte meiosis,gonadal support and germline development.Notably,the effects of TTAC and TTAB in parents were connected with those in the offspring,which highlighted the roles of reproduction in connecting generations.In addition,different effects between TTAC and TTAB demonstrated the anionic influences on the QACs’ toxicities.

关 键 词：Multigenerational effect Oocyte meiosis Gonadal support Germline development Anionic influence 

分 类 号：O64[理学—物理化学]