无机原生细胞的构建及其在细胞仿生和生物催化中的应用进展  

Advancements in the construction of inorganic protocells and their cell mimic and bio‑catalytical applications

作　　者：李兆新 魏瑞波 张敏 王泽峰 郑晶 刘剑波[1] LI Zhaoxin;WEI Ruibo;ZHANG Min;WANG Zefeng;ZHENG Jing;LIU Jianbo(State Key Laboratory of Chemo/Biosensing and Chemometrics,Key Laboratory for Bio-Nanotechnology and Molecular Engineering of Hunan Province,College of Chemistry and Chemical Engineering,Hunan University,Changsha 410082,China)

机构地区：[1]湖南大学化学化工学院,化学生物传感与计量学国家重点实验室,生物纳米与分子工程湖南省重点实验室,长沙410082

出　　处：《无机化学学报》2024年第12期2286-2302,共17页Chinese Journal of Inorganic Chemistry

基　　金：国家自然科学基金(No.22177032,22377025,22305075);湖南省自然科学基金(No.2022RC3047,2021JJ10013)资助。

摘　　要：自下而上构建能够模拟活细胞基本特征的人工区室(原生细胞)的研究正在快速发展。这不仅在非生命与生命之间架起了桥梁,也为生命起源提供了重要的研究线索。此外,无机原生细胞表现出更高的化学和机械稳定性、生物相容性,以及膜设计灵活性。因此,它们具有非常广泛的研究前景,尤其在细胞仿生和生物催化领域展现了巨大潜力。本文介绍了无机原生细胞的基本特征,然后综述了它们的构建方法,重点介绍了无机胶体小体、磁性纳米粒子以及多金属氧簇3种主要腔室类型。最后,讨论了它们在细胞仿生和生物催化中的最新应用,并分析了当前的挑战和展望了未来的发展方向。The bottom‑up construction of artificial cell compartments,known as synthetic protocells,that can mimic the fundamental characteristics of living cells,is advancing at a rapid pace.This development not only bridges the gap between non‑living and living entities but also provides crucial insights into the origin of life.Among them,inorganic protocells exhibit higher chemical and mechanical stability,biocompatibility,and flexibility in membrane design.Therefore,they hold great promise for research,particularly in the fields of cell biomimetics and biocatalysis.The article first introduces the basic characteristics of inorganic protocells,including compartmentalization,membrane selectivity,and cascade metabolic networks.Then,it provides an overview of the construction methods of inorganic protocells,with a focus on three main types of compartments:inorganic colloidosomes,magnetic nanoparticles,and polyoxometalates.Finally,it discusses their latest applications in cell biomimetics and biocatalysis,along with an analysis of current challenges and future development prospects.

关 键 词：无机原生细胞 胶体囊 磁性纳米颗粒 多金属氧簇 生物催化 

分 类 号：TB34[一般工业技术—材料科学与工程] Q26[生物学—细胞生物学]