稀土掺杂上转换纳米探针在生物检测中的应用进展  

Progress in the application of rare‑earth‑doped upconversion nanoprobes in biological detection

作　　者：张敬晗 陈冠英 ZHANG Jinghan;CHEN Guanying(School of Chemistry and Chemical Engineering,Harbin Institute of Technology,Harbin 150001,China)

机构地区：[1]哈尔滨工业大学化工与化学学院,哈尔滨150001

出　　处：《无机化学学报》2024年第12期2335-2355,共21页Chinese Journal of Inorganic Chemistry

摘　　要：响应式光学传感器在特异性检测和微定量分析方面展现出广阔的应用前景。稀土掺杂上转换纳米粒子(UCNP)凭借独特的荧光性能、大的反斯托克斯位移、良好的生物相容性和抗自体荧光干扰,可作为新兴光学标记物实现更深层组织的高灵敏度生物检测。本综述重点介绍了基于UCNP荧光纳米探针在生物检测领域的前景及关键应用,包括离子、活性氧、气体和生物分子的特异性检测。此外,本综述还讨论了上转换检测的传感机制以及纳米探针的设计原理,评估了上转换纳米探针在基础研究和临床应用中的未来挑战,旨在为UCNP在生物检测及临床诊断中的广泛应用提供理论支持和实验指导。The responsive optical sensor demonstrates broad potential for specific detection and micro‑quantitative analysis.Rare‑earth‑doped upconversion nanoparticle(UCNP),owing to their unique fluorescence properties,large anti‑Stokes shift,good biocompatibility,and resistance to autofluorescence interference,can serve as emerging optical labels for achieving high‑sensitivity biological detection at deeper tissue levels.This review focuses on the prospects and key applications of UCNP‑based fluorescent nanoprobes in the field of biological detection,including specific detection of ions,reactive oxygen species,gases,and biomolecules.Additionally,this review discusses the sensing mechanisms of upconversion detection and the design principles of nanoprobes,evaluates the future challenges of upconversion nanoprobes in basic research and clinical applications,and aims to provide theoretical support and experimental guidance for the wide application of UCNP in biological detection and clinical diagnosis.

关 键 词：稀土掺杂上转换纳米粒子 生物检测 响应式荧光纳米探针 特异性检测 

分 类 号：O614.33[理学—无机化学] S951.42[理学—化学]