近红外吸收无机纳米材料在肿瘤光热和光动力治疗中的应用研究进展  

Research progress of near‑infrared absorption inorganic nanomaterials in photothermal and photodynamic therapy of tumors

作　　者：陈佳慧 郑婷婷 张秀云[1] 吕伟 CHEN Jiahui;ZHENG Tingting;ZHANG Xiuyun;LÜWei(School of Pharmacy,Shandong University of Traditional Chinese Medicine,Jinan 250355,China)

机构地区：[1]山东中医药大学药学院,济南250355

出　　处：《无机化学学报》2024年第12期2396-2414,共19页Chinese Journal of Inorganic Chemistry

基　　金：山东中医药大学科学研究基金(No.KYZK2024M24)资助。

摘　　要：近年来,非侵入性的光热治疗(photothermal therapy,PTT)和光动力治疗(photodynamic therapy,PDT)在癌症治疗领域蓬勃发展,它们较化疗等传统癌症治疗方法优势众多。在各种类型的癌症PTT和PDT试剂中,一些性质各异的无机纳米材料相较其他光敏材料具有在近红外(near-infrared,NIR)窗口吸收较强的优势,可以实现高效的癌症PTT或PDT。无机纳米材料除单独使用外,也易与其他类型材料、化学试剂或药物结合,构建多功能复合纳米治疗平台,以产生PTT、PDT、化疗等多种疗法的协同效应,增强治疗效果,降低毒副作用,从而提高癌症患者的治愈率。本综述总结了常见的NIR吸收无机纳米材料在癌症PTT和PDT领域的最新研究进展,涉及金属纳米粒子、碳纳米材料、过渡金属碳/氮化物、氧化物和硫族化物、黑磷纳米片以及配合物纳米材料,其中重点介绍了这些无机纳米材料的PTT和PDT性能。最后,展望了用于癌症PTT和PDT的NIR吸收无机纳米系统未来的研究和发展前景。In recent years,non‑invasive photothermal therapy(PTT)and photodynamic therapy(PDT)have been booming in the field of treating cancer.They offer many advantages over chemotherapy and other traditional cancer treatments.Among various types of PTT and PDT agents for cancer,some inorganic nanomaterials with different properties can achieve highly effective cancer PTT or PDT,because compared with other materials,they have the advantage of strong absorption in the near‑infrared(NIR)window.In addition to being used alone,inorganic nanomaterials can also be easily combined with other types of materials,chemical reagents,or drugs to construct multifunctional composite nano‑therapeutic platforms.They are used to produce the synergistic effects of PTT,PDT,chemotherapy,and other therapies,enhance the therapeutic effect,and reduce toxicity and side effects to improve the cure rate of cancer patients.This review summarizes the latest research progress of common NIR inorganic nanomaterials in the field of cancer PTT and PDT,involving metal nanoparticles,carbon nanomaterials,MXenes,transition metal oxides and chalcogenides,black phosphorus nanosheets,and complex nanomaterials.The PTT and PDT therapeutic properties of these inorganic nanomaterials are mainly introduced.Finally,the research and development prospects of NIR inorganic nanosystems for cancer PTT and PDT in the future are put forward.

关 键 词：无机纳米材料 近红外吸收 癌症 光热治疗 光动力治疗 

分 类 号：TB383[一般工业技术—材料科学与工程] TB34