三个四核稀土配合物的晶体结构、DNA作用及抗菌活性  

Crystal structures,DNA action,and antibacterial activities of three tetranuclear lanthanide‑based complexes

作　　者：苗常青[1] 陈凤姣 李文钰 魏淑杰 姚宇晴 王可怡 王妮[1] 辛晓艳 方明 MIAO Changqing;CHEN Fengjiao;LI Wenyu;WEI Shujie;YAO Yuqing;WANG Keyi;WANG Ni;XIN Xiaoyan;FANG Ming(Department of Chemistry,Xinzhou Normal University,Xinzhou,Shanxi 034000,China;College of Chemistry and Materials,Taiyuan Normal University,Jinzhong,Shanxi 030619,China;Department of Chemistry,Hebei Normal University of Science&Technology,Qinhuangdao,Hebei 066004,China)

机构地区：[1]忻州师范学院化学系,忻州034000 [2]太原师范学院化学与材料学院,晋中030619 [3]河北科技师范学院化学系,秦皇岛066004

出　　处：《无机化学学报》2024年第12期2455-2465,共11页Chinese Journal of Inorganic Chemistry

摘　　要：以多齿席夫碱(E)-2-羟基-3-甲氧基-N'-(6-甲氧基吡啶-2-亚甲基)苯并酰肼(H_(2)L)为配体,与Ln(dbm)3·6H_(2)O(Hdbm=二苯甲酰甲烷)反应,通过溶剂热法,成功设计并构筑了3例新的四核稀土配合物[Ln_(4)(dbm)_(6)(L)_(2)(μ_(2)-OCH_(3))_(2)(CH_(3)OH)_(2)]·x CH_(3)OH[Ln=Eu(1)、Tb (2)、Tm (3),x=3 (1)、0 (2)、0 (3)]。单晶X射线衍射结构表明:1~3的结构相似,配位单元主要由4个Ln^(Ⅲ)、6个dbm-、2个L^(2)-、2个μ_(2)-OCH_(3)及2个配位的CH_(3)OH组成。4个中心LnⅢ通过6个μ_(2)-O原子相互连接,呈线型四核结构。固体荧光实验测试表明:1和2在室温下表现出稀土的荧光特征发射峰。此外,抗菌活性研究表明,与配体H_(2)L和稀土离子相比,1~3具有更强的抗菌活性。采用紫外光谱法、循环伏安法和荧光光谱法研究了1~3与小牛胸腺DNA之间的相互作用,结果表明1~3与小牛胸腺DNA的相互作用为插入结合。Three new tetranuclear lanthanide‑based complexes,namely[Ln_(4)(dbm)_(6)(L)_(2)(μ_(2)‑OCH_(3))_(2)(CH_(3)OH)_(2)]·xCH_(3)OH[Ln=Eu(1),Tb(2),and Tm(3);x=3(1),0(2),and 0(3);Hdbm=dibenzoylmethane],were successfully designed and constructed by using a polydentate Schiff base(E)‑2‑hydroxy‑3‑methoxy‑N′‑(6‑methoxy‑pyridine‑2‑methylene)benzoylhydrazine(H_(2)L)reacting with Ln(dbm)_(3)·6H_(2)O via solvothermal method.Single crystal X‑ray diffraction analysis shows that the coordination units of 1‑3 comprise four Ln^(Ⅲ)ions,six dbm-ligands,two L_(2)-ligands,twoμ_(2)‑OCH_(3) ligands,and two coordinated CH_(3)OH molecules.Four central Ln^(Ⅲ)ions are interlinked by sixμ^(2)‑O atoms displaying a linear tetranuclear structure.Solid fluorescence tests show that 1 and 2 exhibited fluorescence emission peaks of Lnions at room temperature.In addition,antibacterial studies indicate that 1‑3 had stronger antibacterial activity than ligand H_(2)L and Lnions.The interaction between 1‑3 and calf thymus DNA(CT‑DNA)was studied by ultraviolet spectroscopy,cyclic voltammetry,and fluorescence spectrometry.The results indicate that 1‑3 are primarily intercalated with CT‑DNA.CCDC:2258753,1;2258754,2;2258756,3.

关 键 词：四核稀土配合物 晶体结构 荧光性质 DNA作用 抗菌活性 

分 类 号：O614.338[理学—无机化学] O614.341[理学—化学] O614.345