线粒体核糖体蛋白基因内含子间最佳匹配片段新对称相对熵分析  

New Symmetric Relative Entropy Analysis of the Optimal Matched Segments Between Introns of Mitochondrial Ribosomal Protein Genes

作　　者：宋鑫伟 李瑞芳[1] 高姗 彭诗雅 邓俊超 田旭 SONG Xinwei;LI Ruifang;GAO Shan;PENG Shiya;DENG Junchao;TIAN Xu(College of Physics and Electronic Information,Inner Mongolia Normal University,Hohhot 010022,Inner Mongolia,China)

机构地区：[1]内蒙古师范大学物理与电子信息学院,内蒙古呼和浩特010022

出　　处：《咸阳师范学院学报》2024年第6期17-23,74,共8页Journal of Xianyang Normal University

基　　金：内蒙古自治区自然科学基金项目(2023MS03019)。

摘　　要：以人类、小鼠、红鳍东方鲀、黑腹果蝇和秀丽隐杆线虫五个物种的线粒体核糖体蛋白基因序列为样本,研究第一内含子与其他内含子之间相互作用的物种差异性。采用Smith-Waterman方法,通过局部比对得到每个基因的第一内含子与其他内含子反向互补序列的最佳匹配片段,将得到的五个物种的最佳匹配片段数据集标准化后,结合新对称相对熵函数,分析其第一内含子与其他内含子之间相互作用的物种差异性。研究表明,每一个物种和其余任意一个物种相比,都有保守的峰值存在,说明每个物种都有其本身的独特特性,可能是由于这些位置存在某些特殊的功能元件导致的,而这些位置处的最佳匹配片段是组成特殊功能元件的关键元素,并且可以体现出物种间的差异性。Mitochondrial ribosomal protein gene sequences from five species,including Homo sapiens,Mus musculus,Fugu rubripes,Drosophila melanogaster and Caenorhabditis elegans,were used as samples to investigate species differences in the interactions between the first intron and other introns.Using the Smith-Waterman method,the optimal matched segments of the reverse complementary sequence between the first intron and other introns of each gene were obtained through local alignment.After standardizing the optimal matched segments dataset of the five species,combined with a new symmetric relative entropy function,the species differences of interactions between the first intron and other introns were analyzed.Research has shown that each species has a conserved peak compared to any other species,indicating that each species has its own unique characteristics,possibly due to the presence of certain special functional elements at these locations.And the optimally matched segments at these positions are key elements that make up special functional components and can reflect differences between species.

关 键 词：内含子 最佳匹配片段 相对位置分布 相互作用 新对称相对熵 

分 类 号：Q61[生物学—生物物理学]