巴西诺卡菌感染致原发性皮肤诺卡菌病1例及文献复习  

A case of primary cutaneous nocardiosis caused by Nocardiabrasiliensis and review of literature

作　　者：储丹凤 晏少琛 毕新岭 倪丹丹 褚楚 谢明晖 CHU Danfeng;YAN Shaochen;BI Xinling;NI Dandan;CHU Chu;XIE Minghui(Department of Dermatology,The First Affiliated Hospital of Naval Medical University,Shanghai 200433,China;Department of Interventional therapy,The First Affiliated Hospital of Naval Medical University,Shanghai 200433,China)

机构地区：[1]海军军医大学第一附属医院皮肤科,上海200433 [2]海军军医大学第一附属医院介入科,上海200433

出　　处：《中国真菌学杂志》2024年第5期502-504,共3页Chinese Journal of Mycology

基　　金：国家重点研发计划[“海洋环境安全保障与岛礁可持续发展”重点专项(2022-2.4)]。

摘　　要：报道1例因巴西诺卡菌感染致原发性皮肤诺卡菌病患者。临床主要表现为左上肢红色结节伴破溃,外院行清创术及抗生素软膏外用,无明显疗效,我院就诊后行脓液细菌培养质谱鉴定报告为巴西诺卡菌,入院进一步治疗。病房外送脓液二代测序技术(next generation sequencing,NGS)测序,结果同质谱鉴定一致,予以复方磺胺甲恶唑片口服及脓肿切开引流,好转后出院,继续口服复方磺胺甲恶唑片及碳酸氢钠片,随访3个半月,患者皮损痊愈未见复发。Acase of primary cutaneous nocardiosiscaused by N.brasiliensis was reported.The patient manifested with red nodules and ulcers onleft upper limbs.Debriding and topical use of antibiotic ointment did not show obvious effect in local hosptal.The pus sample was cultured and the growth of pathogen was identified as Nocardia brasiliensis via mass spectrometry analysis.After admission,the results of pus NGS were consistent with the mass spectrometry.So SMZ tablets were given and incision,drainage of abscess was performed.The lesions improved significantly,and SMZ continued to be taken after discharge.He was followed up 3 and a half months,the skin lesions disappeared and no recurrence.

关 键 词：皮肤溃疡 原发性皮肤诺卡菌病 巴西诺卡菌 

分 类 号：R519.1[医药卫生—内科学]