体细胞核移植技术在肉牛育种上的研究进展  

Advances in Somatic Cell Nuclear Transfer Technology of Beef Cattle

作　　者：陈欢 李楠楠 陈瑞 周金陈 肖鹏 李孟琪 尚江华 Chen Huan;Li Nannan;Chen Rui;Zhou Jinchen;Xiao Peng;Li Mengqi;Shang Jianghua(Guangxi Buffalo Reseaech Institute/Key Laboratory of Guangxi Buffalo Genetics and Breeding/Key Laboratory of Guangxi Buffalo Genetics,Breeding and Reproduction Technology,Ministry of Agriculture and Rural Affairs,Nanning,530001,Guangxi)

机构地区：[1]广西水牛研究所/广西水牛遗传繁育重点实验室/农业农村部水牛遗传繁育技术重点实验室,广西南宁530001

出　　处：《中国畜禽种业》2024年第11期59-67,共9页The Chinese Livestock and Poultry Breeding

基　　金：中央引导地方科技发展资金项目(桂科ZY21195007);广西自然科学基金(2024GXNSFAA010044);国家现代农业产业技术体系广西奶水牛产业创新团队(nycytxgxcxtd-2021-21-01);广西农业科技自筹经费项目(Z201967、Z201965)。

摘　　要：目前,国内肉牛产业发展迅猛,亟需提升养殖效能与肉牛品质。体细胞核移植技术(Somatic cell nuclear transfer, SCNT)作为先进繁殖生物技术,在推动肉牛遗传育种发展上起到了关键作用。该文详细分析了SCNT原理及在国内外肉牛育种上的应用研究现状,探讨其研究进展与提升遗传品质的显著优势。同时,分析了SCNT面临的操作低效、胚胎存活率低及重构胚胎发育异常等挑战,这些限制了SCNT技术在肉牛育种的广泛应用。展望未来,需不断改进SCNT技术,提升克隆效率与存活率,并探索与基因编辑等新兴技术融合,加快肉牛遗传育种工作进展。At present, the domestic beef cattle industry is developing rapidly, and it is urgent to improve the breeding efficiency andbeef cattle quality. Somatic cell nuclear transfer (SCNT), as an advanced reproductive biotechnology, plays a key role in promotingthe development of beef cattle genetics and breeding. In this paper, the principle of SCNT and its application in beef cattle breedingat home and abroad were analyzed in detail, and its progress and significant advantages in improving genetic quality were discussed.At the same time, the challenges of low operation efficiency, low embryo survival rate and abnormal development of reconstructedembryos faced by SCNT were analyzed, which limited the wide application of SCNT technology in beef cattle breeding.Looking forward to the future, it is necessary to continuously improve SCNT technology, improve cloning efficiency and survivalrate, and explore the integration with emerging technologies such as gene editing to accelerate the progress of beef cattle geneticbreeding.

关 键 词：肉牛 遗传育种 体细胞核移植技术 畜牧业 

分 类 号：S828.2[农业科学—畜牧学]