乳腺癌化疗患者癌因性疲乏的潜在剖面分析及其影响因素  

Potential profiling of cancer related fatigue in breast cancer chemotherapy patients and the influencing factors

作　　者：胡小文 杨素娟[1] 吴秀华[1] 郑清 余小琛 高文思 HU Xiaowen;YANG Sujuan;WU Xiuhua;ZHENG Qing;YU Xiaochen;GAO Wenshi(Fujian Medical University School of Oncology/Fujian Provincial Cancer Hospital,Fuzhou 350014,China)

机构地区：[1]福建医科大学肿瘤临床医学院/福建省肿瘤医院,福建省福州市350014

出　　处：《护理实践与研究》2024年第12期1771-1778,共8页Nursing Practice and Research

基　　金：福建省卫生健康委员会医学创新课题(编号:2022CXA030)。

摘　　要：目的探讨乳腺癌化疗患者癌因性疲乏的潜在分类并分析不同类别患者的特征差异。方法选取2021年11月—2022年4月福建省某所三级甲等肿瘤专科医院乳腺内科、乳腺外科住院化疗的223例患者为调查对象,采用一般资料问卷、癌因性疲乏问卷、阿森斯失眠量表和广泛性焦虑量表简版进行问卷调查。采用潜在剖面分析患者癌因性疲乏的潜在分型,采用多元Logistic模型分析不同疲乏分型的影响因素。结果乳腺癌化疗患者的癌因性疲乏分为3种潜在类别,分别命名为“中疲乏-认知障碍型(19.28%)”“低疲乏-情绪稳定型(57.40%)”“高疲乏-情绪不稳定型(23.32%)”。以“低疲乏-情绪稳定型”为参照,失眠(OR=1.141,P=0.009)、年龄(OR=3.231,P=0.000)、运动(OR=0.255,P=0.000)是“中疲乏-认知障碍型”的影响因素,失眠(OR=1.276,P=0.000)、焦虑(OR=1.509,P=0.001)、运动(OR=0.255,P=0.000)和化疗次数(OR=2.252,P=0.004)是“高疲乏-情绪不稳定型”的影响因素。结论乳腺癌化疗患者的癌因性疲乏存在不同的特征群体,医护人员可根据不同类别的乳腺癌化疗患者展开针对性的干预措施以减轻癌因性疲乏。Objective To explore the potential classification of cancer related fatigue in breast cancer chemotherapy patients and analyse the characteristics differences in the different categories of patients.Methods There were 223 patients who were hospitalised for chemotherapy in the Department of Breast Medicine and Department of Breast Surgery of a Class III Grade A specialised oncology hospital in Fujian from November 2021 to April 2022 were selected for the survey,the questionnaires of General Information Questionnaire,Cancer related Fatigue Questionnaire,Ascension Insomnia Inventory,and Generalized Anxiety Inventory Short Version were used to conduct questionnaire surveys.latent profile analysis of cancer-caused fatigue in patients were analysed using potential profiles,and factors influencing different fatigue subtypes were analysed using multivariate Logistic models.Results Cancer related fatigue in breast cancer chemotherapy patients was classified into three potential categories,which were named as“moderate fatigue-cognitive impairment(19.28%)”“low fatigue-emotionally stable(57.40%)”“high fatigue-emotionally unstable(23.3%)”and“high fatigue-emotionally unstable(23.32%)”.“emotionally unstable(23.3%)”.Taking“low fatigue-emotional stability”as a reference,insomnia(OR=1.141,P=0.009),age(OR=3.231,P=0.000),and exercise(OR=0.255,P=0.000)were the influencing factors of“moderate fatiguecognitive impairment”.and insomnia(OR=1.276,P=0.000),anxiety(OR=1.509,P=0.001),exercise(OR=0.255,P=0.000)and number of chemotherapy treatments(OR=2.252,P=0.004)were the influencing factors of“high fatigue-mood instability type”.Conclusion There were different characteristic groups of cancer-caused fatigue in breast cancer chemotherapy patients,and healthcare professionals can launch targeted interventions to reduce cancer related fatigue according to different categories of breast cancer chemotherapy patients.

关 键 词：乳腺癌 化疗 癌因性疲乏 潜在剖面分析 影响因素 分析 

分 类 号：R473.5[医药卫生—护理学]