2022-2023年凉山地区住院新生儿轮状病毒感染特征多中心研究  

Characteristics of rotavirus infection in newborns hospitalized in a hospital from 2022 to 2023 in Liangshan Prefecture

作　　者：罗吉平[1] 俞琼 宋丽娟 肖晨曦 罗刚群 蔡钊 徐涛[4] 叶如聪 李兴凤 陈启雄 Luo Jiping;Yu Qiong;Song Lijuan;Xiao Chenxi;Luo Gangqun;Cai Zhao;Xu Tao;Ye Rucong;Li Xingfeng;Chen Qixiong(Department of Pediatrics,Xichang People's Hospital,Sichuan Xichang 615000,China;Department of Pediatrics,Liangshan Maternal and Child Health Hospital,Sichuan Xichang 615099,China;Department of Pediatrics,Zhaojue County Hospital,Liangshan Prefecture,Sichuan Xichang 616150,China;Department of Pediatrics,Mianning County People's Hospital,Sichuan Xichang 615699,China;Department of Pediatrics,Xichang Maternal and Child Health Hospital,Sichuan Xichang 615050,China;Department of Pediatrics,Yuexi County People's Hospital,Pediatrics,Liangshan Prefecture,Xichang 616650,China;Department of Pediatrics,Chongqing Traditional Chinese Medicine Hospital,Chongqing 400021,China)

机构地区：[1]西昌市人民医院儿科,四川西昌615000 [2]凉山州妇幼保健院儿科,四川西昌615099 [3]凉山州昭觉县医院儿科,四川西昌616150 [4]西昌市冕宁县人民医院儿科,四川西昌615699 [5]西昌市妇幼保健院儿科,四川西昌615050 [6]凉山州越西县人民医院儿科,四川西昌616650 [7]重庆市中医院儿科,重庆400021

出　　处：《新发传染病电子杂志》2024年第5期14-18,共5页Electronic Journal of Emerging Infectious Diseases

基　　金：2021年度凉山州科技计划重点研发项目(21ZDYF0178)。

摘　　要：目的调查2022-2023年凉山地区住院新生儿轮状病毒感染特征,并开展多中心研究,结合数据分析制定防控措施提供科学依据。方法本研究为多中心调查,选取凉山地区6家县市级医院(西昌市人民医院、凉山州妇幼保健院、西昌市妇幼保健院、凉山州昭觉县医院、西昌市冕宁县医院、凉山州越西县医院),采集2022年1月至2023年12月新生儿病房年龄<28d的新生儿大便样本2918份,其中2022年1393份(腹泻样本65份,非腹泻样本1328份),2023年1525份(腹泻样本77份,非腹泻样本1448份),对样本进行轮状病毒检测并分析感染特征。结果在2918份新生儿大便样本中,共检出轮状病毒阳性82份,阳性率为2.81%,其中腹泻新生儿中轮状病毒阳性率为34.51%(49/142),非腹泻新生儿轮状病毒阳性率为1.19%(33/2776),两者阳性率差异显著(P<0.05);呕吐新生儿中轮状病毒阳性率为34.75%(49/141),非呕吐新生儿轮状病毒阳性率为1.19%(33/2777),两者阳性率差异有统计学意义(P<0.05);发热新生儿中轮状病毒阳性率为35.00%(49/140),非发热新生儿轮状病毒阳性率为1.19%(33/2778),两者阳性率差异显著(P<0.05)。新生儿轮状病毒感染全年均可发生,其中7至9月阳性率<1.5%,12月至次年2月阳性率较高,均>4.5%,各月份阳性率差异具有统计学意义(P<0.05),新生儿轮状病毒感染可见明显季节感染高峰,12月至次年2月检出率较高;胎龄、出生体重、喂养方式、新生儿重症监护病房(neonatal intensive care unit,NICU)入住情况均是新生儿感染轮状病毒的危险因素(P<0.05);25.00%的轮状病毒感染患儿出现腹泻症状。结论轮状病毒感染是新生儿腹泻的重要原因,轮状病毒感染高峰期集中于每年的12月至次年2月,不同日龄新生儿轮状病毒感染率差异明显,需加以干预。腹泻、胎龄、喂养方式、出生体重、NICU入住情况是轮状病毒感染的危险因素,应结合轮状病毒流行病学特征,新生�Objective Investigate the characteristics of rotavirus infection in hospitalized newborns in Liangshan area from 2022 to 2023,Based on data analysis,develop prevention and control measures to provide scientific basis.Method This study is a multi-center survey,selecting 6 countylevel hospitals in Liangshan area(Xichang People's Hospital,Liangshan Prefecture Maternal and Child Health Hospital,Xichang Maternal and Child Health Hospital,Liangshan Zhaojue County Hospital,Xichang Mianning County Hospital,and Liangshan Yuexi County Hospital).2918 stool samples were collected from newborns aged<28 days in the neonatal ward from January 2022 to December 2023,including 1393 in 2022(65 diarrhea samples and 1328 non-diarrhea samples),and 1525 in 2023(diarrhea samples 77 samples and 1448 non-diarrhoeal samples),the samples were tested for rotavirus and the infection characteristics were analyzed.Result Among 2918 newborn stool samples,a total of 82 samples were positive for rotavirus,with a positive rate of 2.81%.The positive rate of rotavirus among newborns with diarrhea was 34.51%(49/142).The positive rate of rotavirus in neonates without diarrhea was 1.19%(33/2776),and the positive rate between the two was significantly different(P<0.05);the positive rate of rotavirus in neonates with vomiting was 34.75%(49/141),and the positive rate of rotavirus in neonates with non-diarrhoea was 34.75%(49/141).The positive rate of rotavirus in neonates with vomiting was 1.19%(33/2777),and the difference between the positive rates was significant(P<0.05);the positive rate of rotavirus in neonates with fever was 35.00%(49/140),and the positive rate of rotavirus in neonates with fever was 35.00%(49/140).The positive rate of rotavirus in newborns was 1.19%(33/2778),and there was a significant difference between the two positive rates(P<0.05).Neonatal rotavirus infection can occur throughout the year,with the positive rate from July to September being<1.5%,and the positive rate from December to February being higher,both>4.5%.There is an obvi

关 键 词：新生儿 轮状病毒 感染特征 腹泻 阳性率 

分 类 号：R512.5[医药卫生—内科学]