乙型肝炎病毒感染者血清白细胞介素17、血小板与淋巴细胞比值、血管内皮细胞生长因子表达意义及与疾病进展的相关性探讨  

Expression significance of interleukin 17,platelet to lymphocyte ratio,vascular endothelial growth factor in serum of hepatitis B virus infected patients and their correlation with disease progression

作　　者：倪慧慧 潘高峰 陈舒君 Ni Huihui;Pan Gaofeng;Chen Shujun(Infectious Disease Department,Kunshan First People's Hospital,Jiangsu Kunshan,215300,China)

机构地区：[1]昆山市第一人民医院感染科,江苏昆山215300

出　　处：《新发传染病电子杂志》2024年第5期31-35,共5页Electronic Journal of Emerging Infectious Diseases

摘　　要：目的探讨乙型肝炎病毒(hepatitis B virus,HBV)感染者血清白细胞介素17(interleukin 17,IL17)、血小板与淋巴细胞比值(platelet to lymphocyte ratio,PLR)、血管内皮细胞生长因子(vascular endothelial growth factor,VEGF)表达意义及与疾病进展的相关性。方法选择2022年6月至2024年3月昆山市第一人民医院收治的82例HBV感染者为研究组,根据病情进展程度将82例患者分为A组(慢性乙型肝炎)37例、B组(代偿期肝硬化)24例、C组(失代偿期肝硬化)21例,选择同期30例健康体检者为对照组。此外根据血清HBV DNA载量将HBV感染者分为阴性组18例(<1.0×10^(5)copy/ml)、低载量组26例(1.0×10^(5)~1.0×10^(8)copy/ml)和高载量组38例(>1.0×10^(8)copy/ml)。检测所有受试者的血清IL-17、PLR、VEGF表达水平及HBV DNA载量,分析血清IL-17、PLR、VEGF表达水平与疾病进展相关性。结果研究组患者血清IL-17、PLR、VEGF表达水平明显高于对照组(P<0.05),C组患者血清IL-17、PLR、VEGF水平显著高于B组和A组,而B组患者血清IL-17、PLR、VEGF水平显著高于A组;高载量组患者血清IL-17、PLR、VEGF水平显著高于低载量组和阴性组,而低载量组患者血清IL-17、PLR、VEGF水平显著高于阴性组(均P<0.05);Pearson相关系数分析血清IL-17、PLR、VEGF水平升高与HBV DNA载量、代偿期肝硬化、失代偿期肝硬化呈正相关(P<0.05);多因素Logistic回归分析结果显示,IL-17、PLR、VEGF表达水平升高是疾病进展的危险因素(P<0.05)。血清IL-17、PLR、VEGF联合诊断代偿期肝硬化、失代偿期肝硬化的曲线下面积分别为0.823、0.835。结论血清IL-17、PLR和VEGF作为反映HBV感染及疾病进展的重要生物标志物,其水平变化与HBV DNA载量、代偿期肝硬化和失代偿期肝硬化密切相关。通过监测这些细胞因子的水平变化,有助于我们更准确地评估HBV感染者的病情严重程度及预后风险,为临床诊疗提供有价值的参考依据。Objective To investigate the significance of serum interleukin 17(IL-17),platelet-tolymphocyte ratio(PLR),and vascular endothelial growth factor(VEGF)expression and their correlation with disease progression in hepatitis B virus(HBV)infected patients.Method Eighty-two HBV-infected patients admitted from June 2022 to March 2024 were selected as the study group,and according to the degree of disease progression,the 82 patients were divided into 37 cases of group A(chronic hepatitis B),24 cases of group B(compensated cirrhosis),and 21 cases of group C(decompensated cirrhosis),and 30 healthy medical check-ups were selected as the control group.In addition HBV-infected patients were classified into 18 cases of negative group(<1.0×10^(5)copy/ml),26 cases of low load group(1.0×10^(5)~1.0×10^(8)copy/ml)and 38 cases of high load group(>1.0×10^(8)copy/ml)according to serum HBV DNA load.Serum IL-17,PLR,VEGF expression levels and HBV DNA load were detected in all subjects,and the correlation between serum IL-17,PLR,VEGF expression levels and disease progression was analysed.Result The serum IL-17,PLR,and VEGF expression levels of patients in the study group were significantly higher than those in the control group(P<0.05),and the serum IL-17,PLR,and VEGF levels of patients in group C were significantly higher than those in group B and group A,whereas those in group B were significantly higher than those in group A.The serum IL-17,PLR,and VEGF levels of patients in the high-load group were significantly higher than those in the low-load and negative groups,while serum IL-17,PLR,and VEGF levels in patients in the low-load group were significantly higher than those in the negative group(all P<0.05),Pearson correlation coefficient analyses of elevated serum IL-17,PLR,and VEGF levels were positively correlated with HBV DNA load,compensated cirrhosis,and decompensated cirrhosis(P<0.05),and multifactor Logistic regression analysis showed that elevated IL-17,PLR,and VEGF expression levels were all risk factors for disease progre

关 键 词：乙型肝炎病毒 白细胞介素17 血小板与淋巴细胞比值 血管内皮细胞生长因子 疾病进展 相关性 

分 类 号：R512.62[医药卫生—内科学]