T2DM合并烧伤创面修复术后控糖治疗中瑞格列奈与二甲双胍联用的应用安全性  

Safety of Repaglinide in Combination with Metformin in Postoperative Glycaemic Control Therapy for T2DM Combined with Burn Wound Repair

作　　者：周芳 张育淑 蓝叔龙 陈翠娟 ZHOU Fang;ZHANG Yushu;LAN Shulong;CHEN Cuijuan(The 73rd Army Hospital of the Chinese People's Liberation Army,Xiamen 361000,Fujian,China)

机构地区：[1]中国人民解放军陆军第七十三集团军医院,福建厦门361000

出　　处：《糖尿病新世界》2024年第18期82-85,共4页Diabetes New World

摘　　要：目的探究瑞格列奈与二甲双胍联用在2型糖尿病(type 2 diabetes mellitus,T2DM)合并烧伤创面修复术后控糖治疗中的应用安全性。方法回顾性选取2022年1月—2024年1月中国人民解放军陆军第七十三集团军医院收治的97例T2DM合并烧伤患者的临床资料,均接受创面修复术,并根据不同控糖手段分为常规组(n=48,二甲双胍治疗)、观察组(n=49,二甲双胍联合瑞格列奈治疗),比较两组控糖效果、临床疗效及不良反应总发生率。结果治疗3个月后,观察组糖化血红蛋白、餐后2 h血糖及空腹血糖均低于常规组,差异有统计学意义(P均<0.05)。观察组治疗总有效率高于常规组,差异有统计学意义(P<0.05)。两组不良反应总发生率比较,差异无统计学意义(P>0.05)。结论T2DM合并烧伤患者创面修复术后应用二甲双胍与瑞格列奈联合治疗,控糖及临床疗效显著且应用安全性较高。Objective To investigate the safety of the use of repaglinide in combination with metformin in the treatment of type 2 diabetes mellitus(T2DM)combined with postoperative glycaemic control after burn wound repair.Methods The clinical data of 97 patients with T2DM complicated with burns admitted to the 73rd Army Hospital of the Chinese People's Liberation Army from January 2022 to January 2024 were retrospectively selected.All patients received wound repair and were divided into conventional group(n=48,treated with metformin)and observation group(n=49,treated with metformin combined with reloglinide)according to different glucose control methods.The effect of,glycemic control,clinical efficacy and total incidence of adverse reactions were compared between the two groups.Results After 3 months of treatment,the glycated hemoglobin A1c,2-hour postprandial blood glucose and fasting blood glucose in the observation group were lower than those in the conventional group,and the differences were statistically significant(all P<0.05).The total effective rate of treatment of the observation group was higher than that of the conventional group,and the difference was statistically significant(P<0.05).There was no significant difference in the total incidence of adverse reactions between the two groups(P>0.05).Conclusion The combined treatment of metformin and repaglinide after wound repair in patients with T2DM complicated with burns has significant glucose control and clinical efficacy and high safety.

关 键 词：2型糖尿病 烧伤 二甲双胍 瑞格列奈 控糖治疗 

分 类 号：R587.2[医药卫生—内分泌]