二甲双胍联合阿卡波糖对2型糖尿病患者免疫功能、糖脂代谢的影响  

Effects of Metformin Combined with Acarbose on Immune Function and Glycolipid Metabolism in Patients with Type 2 Diabetes Mellitus

作　　者：张秀丽 余玉花 张文帝 ZHANG Xiuli;YU Yuhua;ZHANG Wendi(Department of Internal Medicine,Fujian Geological Hospital,Fuzhou 350018,Fujian,China)

机构地区：[1]福建省地质医院内科,福建福州350018

出　　处：《糖尿病新世界》2024年第18期86-88,92,共4页Diabetes New World

摘　　要：目的探讨2型糖尿病患者接受二甲双胍与阿卡波糖共治对免疫功能、糖脂代谢的影响。方法选取2022年1月—2024年5月福建省地质医院收治的156例2型糖尿病患者为研究对象,并按照治疗方式的不同分为两组,各78例。对照组接受二甲双胍治疗,观察组接受二甲双胍及阿卡波糖联合治疗,比较两组糖脂代谢状况、免疫功能以及用药安全性。结果治疗后,观察组总胆固醇、空腹血糖、餐后2 h血糖水平均低于对照组,差异有统计学意义(P均<0.05)。治疗后,观察组CD3^(+)、CD4^(+)高于对照组,CD8^(+)低于对照组,差异有统计学意义(P均<0.05)。两组不良反应发生率比较,差异无统计学意义(P>0.05)。结论对2型糖尿病患者施以二甲双胍及阿卡波糖共治,能够更有效地改善机体的糖脂代谢状况以及免疫功能,同时确保用药安全。Objective To investigate the effects of metformin and acarbose on immune function and glycolipid metabolism in patients with type 2 diabetes mellitus.Methods A total of 156 patients with type 2 diabetes mellitus admitted to Fujian Geological Hospital from January 2022 to May 2024 were selected as the research objects,and they were divided into two groups according to different treatment methods,with 78 cases in each group.The control group was treated with metformin,and the observation group was treated with metformin combined with acarbose.The glucose and lipid metabolism,immune function and drug safety were compared between the two groups.Results After treatment,the levels of total cholesterol,fasting plasma glucose and 2-hour postprandial plasma glucose in the observation group were lower than those in the control group,and the differences were statistically significant(all P<0.05).After treatment,CD3^(+)and CD4^(+)in the observation group were higher than those in the control group,and CD8^(+)was lower than that in the control group,the differences were statistically significant(all P<0.05).There was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusion The combination of metformin and acarbose in patients with type 2 diabetes mellitus can more effectively improve the body's glucose and lipid metabolism and immune function,while ensuring the safety of medication.

关 键 词：2型糖尿病 二甲双胍 阿卡波糖 免疫功能 糖脂代谢 

分 类 号：R59[医药卫生—内科学]